Multifunctional Molecular Beacon Micelles for Intracellular mRNA Imaging and Synergistic Therapy in Multidrug-Resistant Cancer Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Advanced functional materials"
DOI: 10.1002/adfm.201701027
Abstract: Multidrug resistance (MDR) resulting from overexpression of P-glycoprotein (Pgp) transporters increases the drug efflux and thereby limits the chemotherapeutic efficacy. It is desirable to administer both an MDR1 gene silencer and a chemotherapeutic agent in… read more here.
Keywords: multidrug; molecular beacon; dox; multidrug resistant ... See more keywords
Ferroptosis‐modulating small molecules for targeting drug‐resistant cancer: Challenges and opportunities in manipulating redox signaling
Sign Up to like & getrecommendations! Published in 2023 at "Medicinal Research Reviews"
DOI: 10.1002/med.21933
Abstract: Ferroptosis is an iron‐dependent cell death program that is characterized by excessive lipid peroxidation. Triggering ferroptosis has been proposed as a promising strategy to fight cancer and overcome drug resistance in antitumor therapy. Understanding the… read more here.
Keywords: resistant cancer; redox; small molecules; drug ... See more keywords
Ferrocene-embedded flavonoids targeting the Achilles heel of multidrug-resistant cancer cells through collateral sensitivity.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.02.064
Abstract: With the aim to develop anticancer agents acting selectively against resistant tumor cells, we investigated ferrocene embedded into chalcone, aurone and flavone skeletons. These compounds were conceived and then investigated based on the concept of… read more here.
Keywords: collateral sensitivity; cancer cells; cancer; resistant cancer ... See more keywords
Ultrasound-Augmented Phase Transition Nanobubbles for Targeted Treatment of Paclitaxel-Resistant Cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.0c00364
Abstract: The paclitaxel (PTX) resistance in most epithelial ovarian cancers (EOCs) with increasing membrane expression of mucin 16 (MUC16) is mediated by the Toll-like receptor-myeloid differentiation factor 2/myeloid differentiation factor 88 (TLR4-MD2/MyD88) signaling pathway. 6-shogaol (6S),… read more here.
Keywords: ultrasound augmented; phase transition; ptx; transition nanobubbles ... See more keywords
G-Protein-Coupled Receptor 120 Mediates DHA-Induced Apoptosis by Regulating IP3R, ROS and, ER Stress Levels in Cisplatin-Resistant Cancer Cells
Sign Up to like & getrecommendations! Published in 2019 at "Molecules and Cells"
DOI: 10.14348/molcells.2019.2440
Abstract: The omega-3 fatty acid docosahexaenoic acid (DHA) is known to induce apoptosis and cell cycle arrest via the induction of reactive oxygen species (ROS) production and endoplasmic reticulum (ER) stress in many types of cancers.… read more here.
Keywords: apoptosis; stress; cancer cells; cancer ... See more keywords
Co-Delivery of Doxorubicin and Verapamil for Treating Multidrug Resistant Cancer Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Pharmaceutical nanotechnology"
DOI: 10.2174/2211738506666180316122620
Abstract: Background - Patients undergoing chemotherapy can develop resistance not only to the administered drug, but also to many other unrelated types of drugs, a phenomenon known as multidrug resistance. One of the most common mechanisms… read more here.
Keywords: doxorubicin; delivery; multidrug resistant; cancer cells ... See more keywords
Molecular Basis of Resveratrol-Induced Resensitization of Acquired Drug-Resistant Cancer Cells
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14030699
Abstract: Multidrug resistance (MDR) to anticancer drugs remains a serious obstacle to the success of cancer chemotherapy. Resveratrol, a polyphenol, present in natural products exerts anticancer activity and acts as a potential MDR inhibitor in various… read more here.
Keywords: resistant cancer; cancer; resveratrol; drug resistant ... See more keywords
Biological Evaluation in Resistant Cancer Cells and Study of Mechanism of Action of Arylvinyl-1,2,4-Trioxanes
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15030360
Abstract: 1,2,4-trioxane is a pharmacophore, which possesses a wide spectrum of biological activities, including anticancer effects. In this study, the cytotoxic effect and anticancer mechanism of action of a set of 10 selected peroxides were investigated… read more here.
Keywords: resistant cancer; mechanism action; cell; mechanism ... See more keywords