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Published in 2017 at "Advanced functional materials"
DOI: 10.1002/adfm.201701027
Abstract: Multidrug resistance (MDR) resulting from overexpression of P-glycoprotein (Pgp) transporters increases the drug efflux and thereby limits the chemotherapeutic efficacy. It is desirable to administer both an MDR1 gene silencer and a chemotherapeutic agent in…
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Keywords:
multidrug;
molecular beacon;
dox;
multidrug resistant ... See more keywords
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Published in 2023 at "Medicinal Research Reviews"
DOI: 10.1002/med.21933
Abstract: Ferroptosis is an iron‐dependent cell death program that is characterized by excessive lipid peroxidation. Triggering ferroptosis has been proposed as a promising strategy to fight cancer and overcome drug resistance in antitumor therapy. Understanding the…
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Keywords:
resistant cancer;
redox;
small molecules;
drug ... See more keywords
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Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.02.064
Abstract: With the aim to develop anticancer agents acting selectively against resistant tumor cells, we investigated ferrocene embedded into chalcone, aurone and flavone skeletons. These compounds were conceived and then investigated based on the concept of…
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Keywords:
collateral sensitivity;
cancer cells;
cancer;
resistant cancer ... See more keywords
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Published in 2020 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.0c00364
Abstract: The paclitaxel (PTX) resistance in most epithelial ovarian cancers (EOCs) with increasing membrane expression of mucin 16 (MUC16) is mediated by the Toll-like receptor-myeloid differentiation factor 2/myeloid differentiation factor 88 (TLR4-MD2/MyD88) signaling pathway. 6-shogaol (6S),…
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Keywords:
ultrasound augmented;
phase transition;
ptx;
transition nanobubbles ... See more keywords
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Published in 2019 at "Molecules and Cells"
DOI: 10.14348/molcells.2019.2440
Abstract: The omega-3 fatty acid docosahexaenoic acid (DHA) is known to induce apoptosis and cell cycle arrest via the induction of reactive oxygen species (ROS) production and endoplasmic reticulum (ER) stress in many types of cancers.…
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Keywords:
apoptosis;
stress;
cancer cells;
cancer ... See more keywords
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Published in 2018 at "Pharmaceutical nanotechnology"
DOI: 10.2174/2211738506666180316122620
Abstract: Background - Patients undergoing chemotherapy can develop resistance not only to the administered drug, but also to many other unrelated types of drugs, a phenomenon known as multidrug resistance. One of the most common mechanisms…
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Keywords:
doxorubicin;
delivery;
multidrug resistant;
cancer cells ... See more keywords
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Published in 2022 at "Nutrients"
DOI: 10.3390/nu14030699
Abstract: Multidrug resistance (MDR) to anticancer drugs remains a serious obstacle to the success of cancer chemotherapy. Resveratrol, a polyphenol, present in natural products exerts anticancer activity and acts as a potential MDR inhibitor in various…
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Keywords:
resistant cancer;
cancer;
resveratrol;
drug resistant ... See more keywords
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Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15030360
Abstract: 1,2,4-trioxane is a pharmacophore, which possesses a wide spectrum of biological activities, including anticancer effects. In this study, the cytotoxic effect and anticancer mechanism of action of a set of 10 selected peroxides were investigated…
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Keywords:
resistant cancer;
mechanism action;
cell;
mechanism ... See more keywords