Heterochiral β-Peptide Polymers Combating Multidrug-Resistant Cancers Effectively without Inducing Drug Resistance.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c00452
Abstract: Multidrug resistance to chemotherapeutic drugs is one of the major causes for the failure of cancer treatment. Therefore, there is an urgent need to develop anticancer agents that can combat multidrug-resistant cancers effectively and mitigate… read more here.
Keywords: resistant cancers; peptide polymers; resistance; multidrug resistant ... See more keywords
Targeting phase separation on enhancers induced by transcription factor complex formations as a new strategy for treating drug-resistant cancers
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1024600
Abstract: The limited options for treating patients with drug-resistant cancers have emphasized the need to identify alternative treatment targets. Tumor cells have large super-enhancers (SEs) in the vicinity of important oncogenes for activation. The physical process… read more here.
Keywords: phase separation; drug; resistant cancers; drug resistant ... See more keywords