Activity of Combined Antifungal Agents Against Multidrug-Resistant Candida glabrata Strains
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DOI: 10.1007/s11046-017-0141-9
Abstract: In this study, we evaluated the in vitro activity of echinocandins, azoles, and amphotericin B alone and in combination against echinocandin/azole-sensitive and echinocandin/azole-resistant Candida glabrata isolates. Susceptibility tests were performed using the broth microdilution method… read more here.
Keywords: glabrata strains; glabrata; multidrug resistant; resistant candida ... See more keywords
Repurposing approach identifies pitavastatin as a potent azole chemosensitizing agent effective against azole-resistant Candida species
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DOI: 10.1038/s41598-020-64571-7
Abstract: The limited number of antifungals and the rising frequency of azole-resistant Candida species are growing challenges to human medicine. Drug repurposing signifies an appealing approach to enhance the activity of current antifungal drugs. Here, we… read more here.
Keywords: candida species; pitavastatin potent; azole resistant; resistant candida ... See more keywords
Current treatment options for vulvovaginal candidiasis caused by azole-resistant Candida species
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DOI: 10.1080/14656566.2018.1476490
Abstract: ABSTRACT Introduction: Clinicians are increasingly challenged by patients with refractory vulvovaginal candidiasis (VVC) caused by azole-resistant Candida species. Fluconazole resistant C.albicans is a growing and perplexing problem following years of indiscriminate drug prescription and unnecessary… read more here.
Keywords: vulvovaginal candidiasis; treatment options; azole resistant; resistant candida ... See more keywords
Genotypic, proteomic, and phenotypic approaches to decipher the response to caspofungin and calcineurin inhibitors in clinical isolates of echinocandin-resistant Candida glabrata
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DOI: 10.1093/jac/dkab454
Abstract: Abstract Background Echinocandin resistance represents a great concern, as these drugs are recommended as first-line therapy for invasive candidiasis. Echinocandin resistance is conferred by mutations in FKS genes. Nevertheless, pathways are crucial for enabling tolerance,… read more here.
Keywords: response; caspofungin; response caspofungin; resistance ... See more keywords
Antifungal and sensitizing effect of cadinane-type sesquiterpenes from Heterotheca inuloides Cass. against azole-resistant Candida species.
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DOI: 10.1093/jambio/lxaf160
Abstract: AIMS To evaluate the antifungal activity of sesquiterpenes from Heterotheca inuloides, estimate their sensitizing activity against resistant Candida glabrata and C. tropicalis, and elucidate the possible mechanisms of bioactivity through molecular docking. METHODS AND RESULTS… read more here.
Keywords: sesquiterpenes heterotheca; resistant candida; heterotheca inuloides; tropicalis ... See more keywords
Intertriginous ulcers attributable to multidrug‐resistant Candida species
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DOI: 10.1111/ijd.15521
Abstract: drome, inflammatory bowel disease, rheumatoid arthritis, and Mycoplasma pneumoniae infection, as in our case. SPD can also precede the manifestation of underlying malignancies, in particular IgA myeloma. The pathogenesis of SPD remains unclear. It is… read more here.
Keywords: ulcers attributable; spd; multidrug resistant; intertriginous ulcers ... See more keywords
Fluconazole‐resistant Candida parapsilosis genotypes from hospitals located in five Spanish cities and one in Italy: Description of azole‐resistance profiles associated with the Y132F ERG11p substitution
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DOI: 10.1111/myc.13706
Abstract: Fluconazole‐resistant Candida parapsilosis is a matter of concern. read more here.
Keywords: fluconazole resistant; resistant candida; parapsilosis genotypes; candida parapsilosis ... See more keywords
Fungicidal Potency and Mechanisms of θ-Defensins against Multidrug-Resistant Candida Species
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DOI: 10.1128/aac.00111-18
Abstract: ABSTRACT Systemic candidiasis is a growing health care concern that is becoming even more challenging due to the growing frequency of infections caused by multidrug-resistant (MDR) Candida species. Thus, there is an urgent need for… read more here.
Keywords: candida; drug; multidrug resistant; resistant candida ... See more keywords
Potent Synergistic Interactions between Lopinavir and Azole Antifungal Drugs against Emerging Multidrug-Resistant Candida auris
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DOI: 10.1128/aac.00684-20
Abstract: The limited therapeutic options and the recent emergence of multidrug-resistant Candida species present a significant challenge to human medicine and underscore the need for novel therapeutic approaches. Drug repurposing appears as a promising tool to… read more here.
Keywords: multidrug resistant; medicine; candida; resistant candida ... See more keywords
Hospital Clonal Outbreak of Fluconazole-Resistant Candida parapsilosis Harboring the Y132F ERG11p Substitution in a French Intensive Care Unit
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DOI: 10.1128/aac.01130-22
Abstract: We report the first identification of a fluconazole-resistant Candida parapsilosis (FR-Cp) strain in our hospital, which subsequently caused an outbreak involving 17 patients (12 deaths) within a 26-bed French intensive care unit. Microsatellite genotyping confirmed… read more here.
Keywords: fluconazole resistant; candida; french intensive; resistant candida ... See more keywords
Echinocandin-Resistant Candidemia, the Next Upcoming Threat in the Era of Echinocandin Prophylaxis Among Pediatric Hematological Malignancies in Limited Resources Countries
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DOI: 10.1182/blood-2024-211232
Abstract: Background: Hematological cancer patients are at risk for developing candidemia, and echinocandins are commonly employed for prophylaxis in those patients. The rising resistance of Candida spp. to echinocandins poses an emerging threat. Our study aims… read more here.
Keywords: resistant candida; candidemia; echinocandin prophylaxis; candida ... See more keywords