Activity of Combined Antifungal Agents Against Multidrug-Resistant Candida glabrata Strains
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DOI: 10.1007/s11046-017-0141-9
Abstract: In this study, we evaluated the in vitro activity of echinocandins, azoles, and amphotericin B alone and in combination against echinocandin/azole-sensitive and echinocandin/azole-resistant Candida glabrata isolates. Susceptibility tests were performed using the broth microdilution method… read more here.
Keywords: glabrata strains; glabrata; multidrug resistant; resistant candida ... See more keywords
Repurposing approach identifies pitavastatin as a potent azole chemosensitizing agent effective against azole-resistant Candida species
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DOI: 10.1038/s41598-020-64571-7
Abstract: The limited number of antifungals and the rising frequency of azole-resistant Candida species are growing challenges to human medicine. Drug repurposing signifies an appealing approach to enhance the activity of current antifungal drugs. Here, we… read more here.
Keywords: candida species; pitavastatin potent; azole resistant; resistant candida ... See more keywords
Current treatment options for vulvovaginal candidiasis caused by azole-resistant Candida species
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DOI: 10.1080/14656566.2018.1476490
Abstract: ABSTRACT Introduction: Clinicians are increasingly challenged by patients with refractory vulvovaginal candidiasis (VVC) caused by azole-resistant Candida species. Fluconazole resistant C.albicans is a growing and perplexing problem following years of indiscriminate drug prescription and unnecessary… read more here.
Keywords: vulvovaginal candidiasis; treatment options; azole resistant; resistant candida ... See more keywords
Genotypic, proteomic, and phenotypic approaches to decipher the response to caspofungin and calcineurin inhibitors in clinical isolates of echinocandin-resistant Candida glabrata
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DOI: 10.1093/jac/dkab454
Abstract: Abstract Background Echinocandin resistance represents a great concern, as these drugs are recommended as first-line therapy for invasive candidiasis. Echinocandin resistance is conferred by mutations in FKS genes. Nevertheless, pathways are crucial for enabling tolerance,… read more here.
Keywords: response; caspofungin; response caspofungin; resistance ... See more keywords
Intertriginous ulcers attributable to multidrugâresistant Candida species
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DOI: 10.1111/ijd.15521
Abstract: drome, inflammatory bowel disease, rheumatoid arthritis, and Mycoplasma pneumoniae infection, as in our case. SPD can also precede the manifestation of underlying malignancies, in particular IgA myeloma. The pathogenesis of SPD remains unclear. It is… read more here.
Keywords: ulcers attributable; spd; multidrug resistant; intertriginous ulcers ... See more keywords
Fungicidal Potency and Mechanisms of θ-Defensins against Multidrug-Resistant Candida Species
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DOI: 10.1128/aac.00111-18
Abstract: ABSTRACT Systemic candidiasis is a growing health care concern that is becoming even more challenging due to the growing frequency of infections caused by multidrug-resistant (MDR) Candida species. Thus, there is an urgent need for… read more here.
Keywords: candida; drug; multidrug resistant; resistant candida ... See more keywords
Potent Synergistic Interactions between Lopinavir and Azole Antifungal Drugs against Emerging Multidrug-Resistant Candida auris
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DOI: 10.1128/aac.00684-20
Abstract: The limited therapeutic options and the recent emergence of multidrug-resistant Candida species present a significant challenge to human medicine and underscore the need for novel therapeutic approaches. Drug repurposing appears as a promising tool to… read more here.
Keywords: multidrug resistant; medicine; candida; resistant candida ... See more keywords
Hospital Clonal Outbreak of Fluconazole-Resistant Candida parapsilosis Harboring the Y132F ERG11p Substitution in a French Intensive Care Unit
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DOI: 10.1128/aac.01130-22
Abstract: We report the first identification of a fluconazole-resistant Candida parapsilosis (FR-Cp) strain in our hospital, which subsequently caused an outbreak involving 17 patients (12 deaths) within a 26-bed French intensive care unit. Microsatellite genotyping confirmed… read more here.
Keywords: fluconazole resistant; candida; french intensive; resistant candida ... See more keywords
Inhibitory effect of menthol on expression of aspartyl proteinase 1 in fluconazole-resistant Candida albicans
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DOI: 10.15171/jhp.2019.06
Abstract: Introduction: Fluconazole-resistant Candida albicans is one of the biggest problems faced in clinical practice. Using of natural pure compounds such as menthol could be one of the most frequently ways to solve this problem. The… read more here.
Keywords: fluconazole resistant; candida albicans; expression; resistant candida ... See more keywords
Fluconazole-Resistant Candida parapsilosis Bloodstream Isolates with Y132F Mutation in ERG11 Gene, South Korea
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DOI: 10.3201/eid2409.180625
Abstract: We recently observed the emergence of fluconazole-resistant Candida parapsilosis bloodstream isolates harboring a Y132F substitution in Erg11p in South Korea. These Y132F isolates had a higher propensity to cause clonal transmission than other fluconazole-resistant isolates… read more here.
Keywords: candida parapsilosis; south korea; fluconazole resistant; resistant candida ... See more keywords
Antifungal Activity of Minocycline and Azoles Against Fluconazole-Resistant Candida Species
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DOI: 10.3389/fmicb.2021.649026
Abstract: Candida species are the most common fungal pathogens to infect humans, and can cause life-threatening illnesses in individuals with compromised immune systems. Fluconazole (FLU) is the most frequently administered antifungal drug, but its therapeutic efficacy… read more here.
Keywords: candida; flu; resistant candida; min ... See more keywords