Identification of chemoresistance‐related mRNAs based on gemcitabine‐resistant pancreatic cancer cell lines
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DOI: 10.1002/cam4.2764
Abstract: Gemcitabine (GEM) alone and GEM‐based chemotherapy are the preferred regimens for treating advanced unresectable and metastatic pancreatic cancer (PC). However, these treatments have limited efficacy due to acquired resistance of cancer cells to chemotherapy, the… read more here.
Keywords: gem; cell lines; pancreatic cancer; resistant cell ... See more keywords
P3.01-29 St.Iv Lung Adenocarcinoma Treated by First-Line EGFR–Tyrosine Kinase Inhibitors-Survival, EGFR Mutation, Histologic Subtype
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thoracic Oncology"
DOI: 10.1016/j.jtho.2018.08.1589
Abstract: selected variants of the H1650 and H1975 cell lines for resistance to osimertinib to create models in which mechanisms of resistance can be characterized and tested for potential methods to overcome that resistance. Method: Cells… read more here.
Keywords: cell lines; resistance; osimertinib; resistant cell ... See more keywords
Engineering death resistance in CHO cells for improved perfusion culture
Sign Up to like & getrecommendations! Published in 2022 at "mAbs"
DOI: 10.1080/19420862.2022.2083465
Abstract: ABSTRACT The reliable and cost-efficient manufacturing of monoclonal antibodies (mAbs) is essential to fulfil their ever-growing demand. Cell death in bioreactors reduces productivity and product quality, and is largely attributed to apoptosis. In perfusion bioreactors,… read more here.
Keywords: culture; cell; resistant cell; death ... See more keywords
Characterization of the Newly Established Homoharringtonine- (HHT-) Resistant Cell Lines and Mechanisms of Resistance
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/2813938
Abstract: Homoharringtonine- (HHT-) based HHT, aclarubicin, and cytarabine (HAA) induction regimen is the first-line therapy for nonelder acute myeloid leukemia (AML) patients in China. However, drug resistance is a new challenge, and little attention has been… read more here.
Keywords: hht resistant; resistance; hht; resistant cell ... See more keywords
Induction of immunoglobulin transcription factor 2 and resistance to MEK inhibitor in melanoma cells
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DOI: 10.18632/oncotarget.17866
Abstract: Primary or acquired resistance to MEK inhibitors has been a barrier to successful treatment with MEK inhibitors in many tumors. In this study, we analyzed genome-wide gene expression profiling data from 6 sensitive and 6… read more here.
Keywords: resistance mek; transcription factor; resistance; mek ... See more keywords
Acquired AKT-inhibitor Resistance Is Mediated by ATP-binding Cassette Transporters in Endometrial Carcinoma
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DOI: 10.21873/anticanres.16417
Abstract: Background/Aim: Endometrial cancer is increasing in prevalence worldwide. It is treated with chemotherapy and radiotherapy, in addition to surgery, but the presence of treatment-resistant tumor cells remains a barrier to effective tumor control. The purpose… read more here.
Keywords: endometrial cancer; cell; resistant cell; cell line ... See more keywords
1,4-Naphthoquinone (CNN1) Induces Apoptosis through DNA Damage and Promotes Upregulation of H2AFX in Leukemia Multidrug Resistant Cell Line
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158105
Abstract: The multidrug resistance (MDR) phenotype is one of the major obstacles in the treatment of chronic myeloid leukemia (CML) in advantage stages such as blast crisis. In this scenario, more patients develop resistance mechanisms during… read more here.
Keywords: cell; resistant cell; cell line; leukemia ... See more keywords