A novel synthetic peptide inspired on Lys49 phospholipase A2 from Crotalus oreganus abyssus snake venom active against multidrug-resistant clinical isolates.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.02.055
Abstract: Currently, the evolving and complex mechanisms of bacterial resistance to conventional antibiotics are increasing, while alternative medicines are drying up, which urges the need to discover novel agents able to kill antibiotic-resistant bacteria. Lys49 phospholipase… read more here.
Keywords: lys49 phospholipase; abyssus snake; oreganus abyssus; resistant clinical ... See more keywords
Amphipathic Barbiturates as Mimics of Antimicrobial Peptides and the Marine Natural Products Eusynstyelamides with Activity against Multi-resistant Clinical Isolates.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00734
Abstract: We report a series of synthetic cationic amphipathic barbiturates inspired by the pharmacophore model of small antimicrobial peptides (AMPs) and the marine antimicrobials eusynstyelamides. These N,N'-dialkylated-5,5-disubstituted barbiturates consist of an achiral barbiturate scaffold with two… read more here.
Keywords: amphipathic barbiturates; barbiturates mimics; resistant clinical; multi resistant ... See more keywords
Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkx270
Abstract: Abstract Objectives To determine whether the spectrum of mutations in marR in ciprofloxacin-resistant clinical isolates of Escherichia coli shows evidence of selection bias, either to reduce fitness costs, or to increase drug resistance. MarR is… read more here.
Keywords: ciprofloxacin resistant; mutations marr; escherichia coli; resistant clinical ... See more keywords
Competitive Fitness of Fluconazole-Resistant Clinical Candida albicans Strains
Sign Up to like & getrecommendations! Published in 2017 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00584-17
Abstract: ABSTRACT The pathogenic yeast Candida albicans can develop resistance to the widely used antifungal agent fluconazole, which inhibits ergosterol biosynthesis. Resistance is often caused by gain-of-function mutations in the transcription factors Mrr1 and Tac1, which… read more here.
Keywords: resistant clinical; drug; fluconazole resistant; resistance ... See more keywords
Nano-Conversion of Ineffective Cephalosporins into Potent One against Resistant Clinical Uro-Pathogens via Gold Nanoparticles
Sign Up to like & getrecommendations! Published in 2023 at "Nanomaterials"
DOI: 10.3390/nano13030475
Abstract: Infections caused by resistant bacterial pathogens have increased the complications of clinicians worldwide. The quest for effective antibacterial agents against resistant pathogens has prompted researchers to develop new classes of antibiotics. Unfortunately, pathogens have acted… read more here.
Keywords: gold nanoparticles; electron microscopy; microscopy; nano conversion ... See more keywords
Antibacterial Effects of Artemisia afra Leaf Crude Extract Against Some Selected Multi-Antibiotic Resistant Clinical Pathogens
Sign Up to like & getrecommendations! Published in 2022 at "Ethiopian Journal of Health Sciences"
DOI: 10.4314/ejhs.v32i3.22
Abstract: Background Due to improper use of antibiotics, some pathogenic bacteria that cause serious and deadly infections have become resistant to commonly used broad spectrum antibiotics. This antibiotic resistance has become major global healthcare problem. Therefore,… read more here.
Keywords: extract; multi antibiotic; clinical pathogens; antibiotic resistant ... See more keywords