One-Year Outcomes Following Intravenous Ketamine Plus Digital Training Among Patients with Treatment-Resistant Depression
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2023.12434
Abstract: This secondary analysis of a randomized clinical trial examines whether automated self-association training can prolong the antidepressant effect of a single infusion of ketamine beyond 1 month in patients with treatment-resistant depression. read more here.
Keywords: resistant depression; patients treatment; training; treatment resistant ... See more keywords
Association of Treatment-Resistant Depression With Patient Outcomes and Health Care Resource Utilization in a Population-Wide Study
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Psychiatry"
DOI: 10.1001/jamapsychiatry.2022.3860
Abstract: This cohort study examines data for episodes of unipolar major depressive disorder that met criteria for treatment-resistant depression to assess its impact on individuals and society and consider potential prognostic factors. read more here.
Keywords: resistant depression; study; association treatment; treatment resistant ... See more keywords
Finding factors that predict treatment‐resistant depression: Results of a cohort study
Sign Up to like & getrecommendations! Published in 2018 at "Depression and Anxiety"
DOI: 10.1002/da.22774
Abstract: Treatment for depressive disorders often requires subsequent interventions. Patients who do not respond to antidepressants have treatment‐resistant depression (TRD). Predicting who will develop TRD may help healthcare providers make more effective treatment decisions. We sought… read more here.
Keywords: treatment resistant; finding factors; treatment; resistant depression ... See more keywords
Changes in white matter microstructure following serial ketamine infusions in treatment resistant depression
Sign Up to like & getrecommendations! Published in 2023 at "Human Brain Mapping"
DOI: 10.1002/hbm.26217
Abstract: Ketamine produces fast‐acting antidepressant effects in treatment resistant depression (TRD). Though prior studies report ketamine‐related changes in brain activity in TRD, understanding of ketamine's effect on white matter (WM) microstructure remains limited. We thus sought… read more here.
Keywords: resistant depression; white matter; matter microstructure; depression ... See more keywords
Vagal Nerve Stimulation for Treatment-Resistant Depression
Sign Up to like & getrecommendations! Published in 2017 at "Neurotherapeutics"
DOI: 10.1007/s13311-017-0537-8
Abstract: Major depressive disorder (MDD) is prevalent. Although standards antidepressants are more effective than placebo, up to 35% of patients do not respond to 4 or more conventional treatments and are considered to have treatment-resistant depression… read more here.
Keywords: treatment resistant; nerve stimulation; stimulation; treatment ... See more keywords
Dextromethorphan/quinidine pharmacotherapy in patients with treatment resistant depression: A proof of concept clinical trial.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2017.04.072
Abstract: BACKGROUND At least one-third of patients with major depressive disorder (MDD) have treatment-resistant depression (TRD), defined as lack of response to two or more adequate antidepressant trials. For these patients, novel antidepressant treatments are urgently… read more here.
Keywords: clinical trial; depression; treatment resistant; treatment ... See more keywords
Treatment-resistant depression and suicidality.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2018.04.016
Abstract: BACKGROUND Thirty percent of patients with treatment-resistant depression (TRD) attempt suicide at least once during their lifetime. However, it is unclear what the attempted and completed suicide incidences are in TRD patients after initiating a… read more here.
Keywords: treatment resistant; suicide incidences; treatment; suicidality ... See more keywords
Functional disconnectivity of the hippocampal network and neural correlates of memory impairment in treatment-resistant depression.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2019.04.096
Abstract: BACKGROUND Major depressive disorder (MDD) is a disabling neuropsychiatric condition associated with cognitive impairment. Neuroimaging studies have consistently linked memory deficits with hippocampal atrophy in MDD patients. However, there has been a paucity of research… read more here.
Keywords: treatment resistant; hippocampus; resistant depression; memory deficits ... See more keywords
Concordance between clinician-rated and patient reported outcome measures of depressive symptoms in treatment resistant depression.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2020.01.108
Abstract: BACKGROUND Calls to implement measurement-based care (MBC) in psychiatry are increasing. A recent Cochrane meta-analysis concluded that there is insufficient evidence that routine application of patient reported outcomes (PROs) improves treatment outcomes for common psychiatric… read more here.
Keywords: depression; treatment resistant; treatment; resistant depression ... See more keywords
Predictors of cognitive impairment in treatment-resistant depression.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2020.05.101
Abstract: BACKGROUND Cognitive impairment is a well-recognized symptom of major depressive disorder; however, contributing factors are not fully characterized. The present study examined the neurocognitive profiles and predictors of cognitive impairment in patients with treatment-resistant depression… read more here.
Keywords: treatment resistant; predictors cognitive; resistant depression; cognitive impairment ... See more keywords
Neurocognitive performance of repeated versus single intravenous subanesthetic ketamine in treatment resistant depression.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2020.08.058
Abstract: BACKGROUND Ketamine demonstrated rapid antidepressant effects in treatment-resistant depression (TRD). However, evaluation of ketamine's neurocognitive effect in TRD is unclear. We aim to (1) characterize baseline neurocognitive performance as a predictor of the change in… read more here.
Keywords: treatment resistant; treatment; ketamine; resistant depression ... See more keywords