Efficacy and Safety of Dietary Therapies for Childhood Drug-Resistant Epilepsy: A Systematic Review and Network Meta-analysis.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA pediatrics"
DOI: 10.1001/jamapediatrics.2022.5648
Abstract: Importance Despite advances in the understanding of dietary therapies in children with drug-resistant epilepsy, no quantitative comparison exists between different dietary interventions. Objective To evaluate the comparative efficacy and safety of various dietary therapies in… read more here.
Keywords: dietary therapies; drug resistant; efficacy safety; epilepsy ... See more keywords
miR‐485's anti‐drug resistant epilepsy effects by regulating SV2A/PSD‐95 and targeting ABCC1 and neuronal signaling‐transduction proteins in hippocampus of rats
Sign Up to like & getrecommendations! Published in 2021 at "Brain and Behavior"
DOI: 10.1002/brb3.2247
Abstract: Drug‐resistant epilepsy (DRE), most subsequently developing refractory epilepsy, causes a significant burden to the society. microRNAs have been demonstrated as key regulators and therapeutic targets in epilepsy. Accordingly, the aim of the present study was… read more here.
Keywords: epilepsy; mir 485; resistant epilepsy; drug resistant ... See more keywords
Combined use of the ketogenic diet and vagus nerve stimulation in pediatric drug‐resistant epilepsy
Sign Up to like & getrecommendations! Published in 2021 at "Epilepsia Open"
DOI: 10.1002/epi4.12453
Abstract: Patients with drug‐resistant epilepsy (DRE) pose considerable management challenges for patients, their families, and providers. Both the vagus nerve stimulator (VNS) and the ketogenic diet (KD) have been shown to be safe and effective in… read more here.
Keywords: epilepsy; resistant epilepsy; drug resistant; vagus nerve ... See more keywords
Introduction to the special issue “Redesigning the hypotheses for drug‐resistant epilepsy”
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DOI: 10.1002/epi4.12582
Abstract: Drug‐resistant epilepsy represents an important neurological condition. Its prevalence is not modified in spite of the different hypotheses established to understand the mechanisms involved. The special issue “Redesigning the hypotheses for drug‐resistant epilepsy” represents an… read more here.
Keywords: resistant epilepsy; issue redesigning; drug resistant; epilepsy ... See more keywords
Analysis of hematological parameters in patients treated with ketogenic diet due to drug-resistant epilepsy
Sign Up to like & getrecommendations! Published in 2017 at "Neurological Sciences"
DOI: 10.1007/s10072-017-3152-x
Abstract: Benefits of the ketogenic diet (KD) in epileptic patients are well known while less is known about the nutritional risks of the diet and its potential impacts on biochemical nutritional status. In this study, we… read more here.
Keywords: resistant epilepsy; drug resistant; hematological parameters; month ... See more keywords
The current and emerging therapeutic approaches in drug-resistant epilepsy management
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neurologica Belgica"
DOI: 10.1007/s13760-019-01120-8
Abstract: Epilepsy is a neurologic disorder consisting of recurrent spontaneous seizures. Antiepileptic drugs administration is the most commonly used therapeutic strategy in the management of epilepsy. However, 20–30% of epilepsy patients have seizure episodes that are… read more here.
Keywords: epilepsy; therapeutic approaches; resistant epilepsy; drug resistant ... See more keywords
A functional SNP in miR-146a and genetic susceptibility to drug-resistant epilepsy.
Sign Up to like & getrecommendations! Published in 2023 at "Neurological research"
DOI: 10.1080/01616412.2023.2203617
Abstract: OBJECTIVES The study aimed to assess the relationship between the functional single nucleotide polymorphism (SNP) (rs57095329) of miR-146a, the progression of drug-resistant epilepsy (DRE), and the severity of the disease (seizure frequency) in a group… read more here.
Keywords: mir 146a; snp; drug resistant; drug ... See more keywords
The place of a ketogenic diet in the treatment of resistant epilepsy: a comprehensive review.
Sign Up to like & getrecommendations! Published in 2022 at "Nutritional neuroscience"
DOI: 10.1080/1028415x.2022.2095819
Abstract: OBJECTIVE The ketogenic diet (KD) is a high-fat, adequate-protein, and low-carb diet. Ketone bodies increase in the blood due to low carbohydrate content and high-fat content in the diet. The most important feature of the… read more here.
Keywords: treatment resistant; treatment; place; resistant epilepsy ... See more keywords
Cannabidiol Add-On in Glycosylphosphatidylinositol-Related Drug-Resistant Epilepsy.
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DOI: 10.1089/can.2022.0255
Abstract: Background: Glycosylphosphatidylinositol-anchored protein deficiencies (GPI-ADs) are commonly associated with drug-resistant epilepsy (DRE). Cannabidiol (CBD) is approved for the adjunctive treatment of seizures in Dravet/Lennox-Gastaut Syndromes and Tuberous Sclerosis Complex. We report on the efficacy and… read more here.
Keywords: cbd; drug resistant; epilepsy; treatment ... See more keywords
Neuromodulation in drug‐resistant epilepsy: A review of current knowledge
Sign Up to like & getrecommendations! Published in 2022 at "Acta Neurologica Scandinavica"
DOI: 10.1111/ane.13696
Abstract: Nearly 1% of the global population suffers from epilepsy. Drug‐resistant epilepsy (DRE) affects one‐third of epileptic patients who are unable to treat their condition with existing drugs. For the treatment of DRE, neuromodulation offers a… read more here.
Keywords: resistant epilepsy; neuromodulation; stimulation; drug resistant ... See more keywords
Clinician preferences for neurotechnologies in pediatric drug‐resistant epilepsy: A discrete choice experiment
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia"
DOI: 10.1111/epi.17328
Abstract: Novel and minimally invasive neurotechnologies offer the potential to reduce the burden of epilepsy while avoiding the risks of conventional resective surgery. Few neurotechnologies have been tested in randomized controlled trials with pediatric populations, leaving… read more here.
Keywords: pediatric drug; drug resistant; clinician preferences; epilepsy ... See more keywords