Engineered Phages and Engineered and Recombinant Endolysins Against Carbapenem‐Resistant Gram‐Negative Bacteria: A Focused Review on Novel Antibacterial Strategies
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Basic Microbiology"
DOI: 10.1002/jobm.70078
Abstract: Antibiotic resistance has escalated globally, affecting not only commonly used antibiotics but also last‐resort agents such as carbapenems and colistin. The rise of antibiotic‐resistant bacteria has prompted microbiologists to devise new strategies, with bacteriophages emerging… read more here.
Keywords: resistant gram; resistance; gram negative; negative bacteria ... See more keywords
Salvaging lives in carbapenem-resistant Gram-negative osteoarticular and soft tissue infections: early compromises save lives
Sign Up to like & getrecommendations! Published in 2022 at "International Orthopaedics"
DOI: 10.1007/s00264-022-05342-z
Abstract: Incidence of carbapenem-resistant Gram-negative infections has risen alarmingly all across the globe, both in developed and developing countries alike. The purpose of this study was to assess whether challenges of life-threatening infections with very high… read more here.
Keywords: gram negative; soft tissue; carbapenem resistant; resistant gram ... See more keywords
Active surveillance culture program in asymptomatic patients as a strategy to control multidrug-resistant gram-negative organisms: What should be considered?
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Formosan Medical Association = Taiwan yi zhi"
DOI: 10.1016/j.jfma.2019.08.015
Abstract: The increasing burden of multidrug-resistant gram-negative bacilli (MDR-GNB) infection has highlighted the urgent requirement for efficient prevention and control strategies. A routine active surveillance culture (ASC) program of asymptomatic carriers as part of an infection… read more here.
Keywords: active surveillance; gram negative; program; multidrug resistant ... See more keywords
A method to quantify viable carbapenem resistant gram-negative bacteria in treated and untreated wastewater.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of microbiological methods"
DOI: 10.1016/j.mimet.2020.106070
Abstract: Carbapenem resistance, particularly in Enterobacteriaceae, is an urgent threat to public health worldwide. Wastewater treatment plants are a critical control point for the spread of antimicrobial resistance into the environment yet, due in part to… read more here.
Keywords: viable carbapenem; supplemented media; wastewater; carbapenem resistant ... See more keywords
Colistin-based Treatment of Multidrug-resistant Gram-negative Bacterial Pulmonary Infections After Lung Transplantation.
Sign Up to like & getrecommendations! Published in 2019 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2018.04.068
Abstract: BACKGROUND Lung transplantation (LT) is a viable option for a select group of patients with end-stage lung disease. However, infections are a major complication after LT, accounting for significant morbidity and mortality. Several germs may… read more here.
Keywords: colistin; treatment; lung transplantation; transplantation ... See more keywords
Epidemiology of resistant gram-negative bacteria in nursing homes.
Sign Up to like & getrecommendations! Published in 2023 at "Infection control and hospital epidemiology"
DOI: 10.1017/ice.2022.225
Abstract: BACKGROUND Resistant gram-negative bacteria (R-GNB) colonization in nursing home patients can cause clinical infection and intrafacility transmission. Limited data exist on the roles of age and function on R-GNB colonization. METHODS A secondary data analysis… read more here.
Keywords: nursing homes; colonization; gnb colonization; epidemiology ... See more keywords
Active screening and patient-placement and cohort-placement strategies to decrease carbapenem-resistant gram-negative bacilli colonization and infection in pediatric patients: A 5-year retrospective observational study in China.
Sign Up to like & getrecommendations! Published in 2023 at "Infection control and hospital epidemiology"
DOI: 10.1017/ice.2023.20
Abstract: Carbapenem-resistant gram-negative bacilli (CR-GNB) colonization screening was initiated across high-risk departments (PICU, NICU, neonatal wards, and hematology departments) in January 2017, and several CR-GNB cohort and patient-placement strategies were introduced throughout the hospital in January… read more here.
Keywords: carbapenem resistant; colonization; placement; infection ... See more keywords
Discovery of Macrolide Antibiotics Effective against Multi-Drug Resistant Gram-Negative Pathogens.
Sign Up to like & getrecommendations! Published in 2021 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.1c00020
Abstract: ConspectusMacrolides are among the most widely prescribed antibiotics, particularly for bacterial lung infections, due to their favorable safety, oral bioavailability, and spectrum of activity against Gram-positive pathogens such as Streptococcus pneumoniae, the most common cause… read more here.
Keywords: gram negative; gram; drug resistant; multi drug ... See more keywords
Identification of 5-(Aryl/Heteroaryl)amino-4-quinolones as Potent Membrane-Disrupting Agents to Combat Antibiotic-Resistant Gram-Positive Bacteria.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01151
Abstract: Nosocomial infections caused by resistant Gram-positive organisms are on the rise, presumably due to a combination of factors including prolonged hospital exposure, increased use of invasive procedures, and pervasive antibiotic therapy. Although antibiotic stewardship and… read more here.
Keywords: gram; identification; positive bacteria; amino quinolones ... See more keywords
Multiantigenic Nanotoxoids for Antivirulence Vaccination against Antibiotic-Resistant Gram-Negative Bacteria.
Sign Up to like & getrecommendations! Published in 2019 at "Nano letters"
DOI: 10.1021/acs.nanolett.9b01844
Abstract: Infections caused by multidrug-resistant Gram-negative bacteria have emerged as a major threat to public health worldwide. The high mortality and prevalence, along with the slow pace of new antibiotic discovery, highlight the necessity for new… read more here.
Keywords: antivirulence; gram negative; negative bacteria; multiantigenic nanotoxoids ... See more keywords
3-O-Substituted Quercetin: an Antibiotic-Potentiating Agent against Multidrug-Resistant Gram-Negative Enterobacteriaceae through Simultaneous Inhibition of Efflux Pump and Broad-Spectrum Carbapenemases.
Sign Up to like & getrecommendations! Published in 2024 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.3c00715
Abstract: The discovery of safe and efficient inhibitors against efflux pumps as well as metallo-β-lactamases (MBL) is one of the main challenges in the development of multidrug-resistant (MDR) reversal agents which can be utilized in the… read more here.
Keywords: broad spectrum; resistant gram; gram negative; multidrug resistant ... See more keywords