Results of an abbreviated phase II study of AKT inhibitor MK-2206 in the treatment of recurrent platinum-resistant high grade serous ovarian, fallopian tube, or primary peritoneal carcinoma (NCT 01283035)
Sign Up to like & getrecommendations! Published in 2020 at "Gynecologic Oncology Reports"
DOI: 10.1016/j.gore.2020.100546
Abstract: Highlights • PI3K/AKT pathway alterations are frequently seen in ovarian cancer, providing rationale for targeted AKT inhibition.• AKT inhibitor MK-2206 in platinum resistant high grade serous ovarian cancer was notable for dermatologic toxicity.• Best response… read more here.
Keywords: grade serous; high grade; inhibitor 2206; resistant high ... See more keywords
Multidrug-resistant high-risk Enterococcus faecium clones: can we really define them?
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DOI: 10.1016/j.ijantimicag.2020.106227
Abstract: Enterococcus faecium is a relevant and opportunistic human pathogen that has a broad host range including humans, farm animals, pets, and wildlife. Specialized sub-populations have globally evolved towards a powerful and convergent adaption to the… read more here.
Keywords: enterococcus faecium; high risk; multidrug resistant; resistant high ... See more keywords
First Report of a Methicillin-Resistant, High-Level Mupirocin-Resistant Staphylococcus argenteus
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DOI: 10.3389/fcimb.2022.860163
Abstract: We describe the identification of a methicillin-resistant, high-level mupirocin-resistant Staphylococcus argenteus. The isolate (1801221) was characterized as t6675-ST2250-SCCmecIVc, and whole-genome sequencing revealed that the isolate possessed two plasmids. One plasmid (34,870 bp), designated p1_1801221 with… read more here.
Keywords: methicillin resistant; level mupirocin; mupirocin resistant; resistant high ... See more keywords