A novel antibacterial compound produced by Lactobacillus plantarum LJR13 isolated from rumen liquor of goat effectively controls multi-drug resistant human pathogens.
Sign Up to like & getrecommendations! Published in 2020 at "Microbiological research"
DOI: 10.1016/j.micres.2020.126563
Abstract: Probiotic lactobacilli have been implicated in the production of many low molecular weight bioactive molecules with tremendous potential to kill multidrug resistant human pathogens. The aim of the present study is to purify, characterise and… read more here.
Keywords: bpbp; compound produced; resistant human; human pathogens ... See more keywords
Site-Specific Chemical Modulation of a Flexible Azaproline Transporter to Enhance Epirubicin Accumulation in Drug-Resistant Human Glioblastoma Cells and Blood-Brain Barrier Penetration in Adult Zebrafish.
Sign Up to like & getrecommendations! Published in 2025 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.4c01029
Abstract: Cell-penetrating peptides (CPPs) have emerged as nonviral biological carriers for the delivery of macromolecular therapeutics into cells. Despite their lower immunogenicity and cellular toxicity, CPPs often lack target specificity and proteolytic stability. Various modified CPPs… read more here.
Keywords: drug; azaproline; resistant human; azaproline transporter ... See more keywords
Polyphyllin I Sensitizes Cisplatin-Resistant Human Cervical Cancer Cells to Cisplatin Treatment
Sign Up to like & getrecommendations! Published in 2024 at "Nutrition and Cancer"
DOI: 10.1080/01635581.2024.2350107
Abstract: Abstract Cervical cancer (CC) is a common gynecological malignancy, and improving cisplatin sensitivity has become a hot topic in CC chemotherapy research. Polyphyllin I (PPI), a potent bioactive compound found in Rhizoma Paridis, known for… read more here.
Keywords: cancer; cisplatin; cisplatin resistant; cervical cancer ... See more keywords
Olaparib Is a Mitochondrial Complex I Inhibitor That Kills Temozolomide-Resistant Human Glioblastoma Cells
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222111938
Abstract: Glioblastoma represents the highest grade of brain tumors. Despite maximal resection surgery associated with radiotherapy and concomitant followed by adjuvant chemotherapy with temozolomide (TMZ), patients have a very poor prognosis due to the rapid recurrence… read more here.
Keywords: inhibitor; glioblastoma; resistant human; tmz ... See more keywords
E7050 Suppresses the Growth of Multidrug-Resistant Human Uterine Sarcoma by Inhibiting Angiogenesis via Targeting of VEGFR2-Mediated Signaling Pathways
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24119606
Abstract: E7050 is an inhibitor of VEGFR2 with anti-tumor activity; however, its therapeutic mechanism remains incompletely understood. In the present study, we aim to evaluate the anti-angiogenic activity of E7050 in vitro and in vivo and… read more here.
Keywords: resistant human; vegfr2; multidrug resistant; human uterine ... See more keywords
Characteristics of doxorubicin-selected multidrug-resistant human leukemia HL-60 cells with tolerance to arsenic trioxide and contribution of leukemia stem cells.
Sign Up to like & getrecommendations! Published in 2018 at "Oncology letters"
DOI: 10.3892/ol.2017.7353
Abstract: The present study selected and characterized a multidrug-resistant HL-60 human acute promyelocytic leukemia cell line, HL-60/RS, by exposure to stepwise incremental doses of doxorubicin. The drug-resistant HL-60/RS cells exhibited 85.68-fold resistance to doxorubicin and were… read more here.
Keywords: arsenic trioxide; resistant human; resistance; multidrug resistant ... See more keywords