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Published in 2020 at "ESC Heart Failure"
DOI: 10.1002/ehf2.12832
Abstract: Hypertension is a major contributor to cardiac diastolic dysfunction. Different therapeutics strategies have been proposed to control blood pressure (BP), but their independent impact on cardiac function remains undetermined. In patients with resistant hypertension, we… read more here.
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Published in 2020 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.1860
Abstract: The AMBER trial demonstrated that concomitant use of patiromer enabled the more persistent use of spironolactone by reducing the risk of hyperkalaemia in patients with resistant hypertension and advanced chronic kidney disease. We report herein… read more here.
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Published in 2021 at "Sleep and Breathing"
DOI: 10.1007/s11325-021-02490-1
Abstract: Epidemiological studies have shown an increased prevalence and incidence of hypertension as well as a higher incidence of stroke among patients suffering from RLS. The objective of this study was to estimate the prevalence of… read more here.
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Published in 2020 at "Current Cardiology Reports"
DOI: 10.1007/s11886-020-01400-3
Abstract: As the global burden of hypertension continues to rise, it remains suboptimally controlled despite increased awareness. Poor medication adherence is a well-recognized although underestimated contributing factor of uncontrolled hypertension. This review focuses on medication non-adherence… read more here.
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Published in 2019 at "Annales de cardiologie et d'angeiologie"
DOI: 10.1016/j.ancard.2019.07.002
Abstract: OBJECTIVES The primary objective was to estimate the proportion of non-adherence to antihypertensive drugs in patients with an apparently resistant hypertension despite optimal medical treatment. The secondary objective was to identify related factors to poor… read more here.
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Published in 2017 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2016.12.158
Abstract: OBJECTIVE The efficacy of add-on use of spironolactone in patients with resistant hypertension has been investigated in several small studies. We performed this meta-analysis evaluating the efficacy of add-on use of spironolactone in these patients.… read more here.
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Published in 2022 at "Life sciences"
DOI: 10.1016/j.lfs.2021.120270
Abstract: Approximately 12-18% of hypertensive patients are diagnosed with resistant hypertension (RH). The risk of having worse cardiovascular outcomes is twice higher in those patients. The low effectiveness of conventional antihypertensive drugs in RH emphasizes the… read more here.
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Published in 2018 at "Medicina clinica"
DOI: 10.1016/j.medcli.2017.06.046
Abstract: INTRODUCTION Resistant hypertension(RH) has been defined as failure to control office blood pressure (BP) despite the use of≥3 different antihypertensive agents at optimal doses, including, ideally, a diuretic. Apparent RH, defines patients with an incorrect… read more here.
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Published in 2020 at "Nefrologia"
DOI: 10.1016/j.nefroe.2020.08.001
Abstract: INTRODUCTION Resistant hypertension (RH) is a significant health problem with complex management. The aim of this study was to evaluate the risks and benefits of adding spironolactone to treat RH. MATERIAL AND METHODS In total,… read more here.
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Published in 2017 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(17)35189-6
Abstract: Aim: The purpose of the study was to investigate the incidence of subclinical atherosclerosis by coronary artery calcium(CAC) score and atherosclerotic cardiovascular disease(ASCVD) risk score in patients with resistant hypertension. Methods: For 8823 subjects taking… read more here.
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Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(18)32292-7
Abstract: Patients with resistant hypertension (rHTN) have uncontrolled hypertension despite receiving at least 3 anti-HTN medication classes. The recent PATHWAY-2 Trial demonstrated superior HTN control when spironolactone was added as a 4th agent in rHTN. However,… read more here.