Independent root cause analysis of contributing factors, including dismantling of 2 duodenoscopes, to an outbreak of multidrug-resistant Klebsiella pneumoniae.
Sign Up to like & getrecommendations! Published in 2019 at "Gastrointestinal endoscopy"
DOI: 10.1016/j.gie.2019.05.016
Abstract: BACKGROUND AND AIMS Worldwide an increasing number of duodenoscope-associated outbreaks are reported. The high prevalence rate of contaminated duodenoscopes puts patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) at risk of exogenous transmission of microorganisms. The contributing… read more here.
Keywords: duodenoscope; contributing factors; multidrug resistant; outbreak multidrug ... See more keywords
Synergistic activity of colistin with azidothymidine against colistin-resistant Klebsiella pneumoniae clinical isolates collected from inpatients in Greek hospitals.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2019.02.021
Abstract: BACKGROUND New antibiotics are urgently needed to treat multi-drug resistant infections; however, production of novel antibiotics is diminishing. Synergistic combination drug therapy to enhance the activity of available antibiotics may improve management of patients with… read more here.
Keywords: activity colistin; colistin; colistin resistant; klebsiella pneumoniae ... See more keywords
Immunomodulatory Effects of Colistin on Host Responses against Carbapenem-resistant Klebsiella pneumoniae Biofilms.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2020.106182
Abstract: Colistin (CST) is a last-resort therapeutic option for carbapenem-resistant Klebsiella pneumoniae (CR-Kp) infections in critically ill patients. The effect of sub-inhibitory CST concentrations (sub-MICs) on biofilm formation is organism-dependent. We investigated the interactions between CST… read more here.
Keywords: cst; sub mics; carbapenem resistant; klebsiella pneumoniae ... See more keywords
In silico study and biological screening of benzoquinazolines as potential antimicrobial agents against methicillin-resistant Staphylococcus aureus, carbapenem-resistant Klebsiella pneumoniae, and fluconazole -resistant Candida albicans.
Sign Up to like & getrecommendations! Published in 2021 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2021.105157
Abstract: Globally, antibiotic-resistant pathogens have become a serious threat to public health. The use of drugs having structures different from those applied in the clinical treatments of bacterial infections is a well-known potential solution to the… read more here.
Keywords: staphylococcus aureus; antimicrobial agents; resistant staphylococcus; methicillin resistant ... See more keywords
What are the treatment options for resistant Klebsiella pneumoniae carbapenemase (KPC)-producing bacteria?
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2020.1779221
Abstract: In recent years, carbapenem-resistant Enterobacteriaceae (CRE) have been recognized as a common cause of healthcare-associated infections, causing high morbidity and mortality rates due to their di... read more here.
Keywords: carbapenemase kpc; treatment options; options resistant; pneumoniae carbapenemase ... See more keywords
Multidrug-resistant Klebsiella pneumoniae: mechanisms of resistance including updated data for novel β-lactam-β-lactamase inhibitor combinations
Sign Up to like & getrecommendations! Published in 2021 at "Expert Review of Anti-infective Therapy"
DOI: 10.1080/14787210.2021.1924674
Abstract: ABSTRACT Introduction: Multi-drug-resistant Klebsiella pneumoniae is currently one of the most pressing emerging issues in bacterial resistance. Treatment of K.pneumoniae infections is often problematic due to the lack of available therapeutic options, with a relevant… read more here.
Keywords: mechanisms resistance; pneumoniae; lactam lactamase; resistance ... See more keywords
In vitro and in vivo activity of meropenem+avibactam against MBL-producing carbapenem-resistant Klebsiella pneumoniae
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Anti-infective Therapy"
DOI: 10.1080/14787210.2022.2153117
Abstract: ABSTRACT Background Antibiotic resistance has become a public health problem to be solved worldwide and metallo-β-lactamase (MBL)-producing bacteria make this problem even more challenging. Methods The interactions of meropenem (MEM) in combination with avibactam (AVI)… read more here.
Keywords: mem avi; producing carbapenem; mbl; carbapenem resistant ... See more keywords
Colistin- and Carbapenem-Resistant Klebsiella pneumoniae Clinical_Isolates: Algeria.
Sign Up to like & getrecommendations! Published in 2019 at "Microbial drug resistance"
DOI: 10.1089/mdr.2018.0147
Abstract: This study investigates the molecular mechanisms of colistin and carbapenem resistance in Klebsiella pneumoniae ST101 strains. The three K. pneumoniae carried blaCTX-M-15, blaTEM-183, and blaSHV-106 genes and two coharbored blaOXA-48. As for colistin resistance, the… read more here.
Keywords: carbapenem resistant; klebsiella pneumoniae; colistin carbapenem; resistant klebsiella ... See more keywords
Prevalence of Carbapenem-Resistant Klebsiella pneumoniae Infection in Southern China: Clinical Characteristics, Antimicrobial Resistance, Virulence, and Geographic Distribution.
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DOI: 10.1089/mdr.2018.0401
Abstract: Carbapenem-resistant Klebsiella pneumoniae (CRKP) strains pose a significant threat to public health. In this study, a survey was conducted in the Jiangxi Province of China, covering a total of 140 CRKP strains collected from 11… read more here.
Keywords: crkp; pneumoniae; resistance; carbapenem resistant ... See more keywords
Antimicrobial resistance pattern, virulence determinants and molecular analysis of carbapenem resistant Klebsiella pneumoniae isolated from clinical samples in Iran.
Sign Up to like & getrecommendations! Published in 2022 at "FEMS microbiology letters"
DOI: 10.1093/femsle/fnac100
Abstract: Carbapenem-resistant Klebsiella pneumoniae (CRKP) has emerged as an important global threats in recent years. The objective of present study was to characterize the molecular characteristic, antibiotic resistance pattern and the distribution of virulence factors in… read more here.
Keywords: carbapenem resistant; klebsiella pneumoniae; carbapenem; virulence ... See more keywords
Risk Factors for Colistin-Resistant Carbapenem-Resistant Klebsiella pneumoniae in the Postacute Care Setting
Sign Up to like & getrecommendations! Published in 2022 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofac452
Abstract: Abstract We assessed risk factors for colistin resistance among carbapenem-resistant Klebsiella pneumoniae (CRKP) from 375 patients in long-term acute care hospitals. Recent colistin or polymyxin B exposure was associated with increased odds of colistin resistance… read more here.
Keywords: carbapenem resistant; klebsiella pneumoniae; risk factors; factors colistin ... See more keywords