SMALL-MOLECULE TELOMERE INHIBITOR ATTENUATES THE LEUKEMIA-INITIATION POTENTIAL IN DRUG-RESISTANT LEUKEMIA CELLS
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DOI: 10.1016/j.exphem.2019.06.364
Abstract: The drug resistance is the most often obstacle in leukemia treatment and failing to eradicating the quiescent leukemia stem cell (LSCs) is believed as the main reason of relapse. Numerous studies have indicated that abnormal… read more here.
Keywords: leukemia; drug; resistant leukemia; drug resistant ... See more keywords
Multifunctional Gold Nanoparticles Overcome MicroRNA Regulatory Network Mediated-Multidrug Resistant Leukemia
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DOI: 10.1038/s41598-019-41866-y
Abstract: Resistance to chemotherapy and molecularly targeted therapies is a major problem in current leukemia treatments. Here, we investigated cross-talk between the miR-221 network and P-glycoprotein (P-gp) in doxorubicin-induced drug resistance of leukemia cells. Multifunctional gold… read more here.
Keywords: multifunctional gold; gold nanoparticles; drug; resistant leukemia ... See more keywords