Orthosteric–allosteric dual inhibitors of PfHT1 as selective antimalarial agents
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2017749118
Abstract: Significance There is an urgent need for alternative antimalarials with the emergence of artemisinin-resistant malaria parasites. Blocking sugar uptake in Plasmodium falciparum by selectively inhibiting the hexose transporter P. falciparum hexose transporter 1 (PfHT1) kills… read more here.
Keywords: orthosteric allosteric; resistant malaria; falciparum; hexose transporter ... See more keywords
Multidrug-resistant malaria and the impact of mass drug administration
Sign Up to like & getrecommendations! Published in 2018 at "Infection and Drug Resistance"
DOI: 10.2147/idr.s123887
Abstract: Based on the emergence and spread throughout the Greater Mekong Subregion (GMS) of multiple artemisinin-resistant lineages, the prevalence of multidrug resistance leading to high rates of artemisinin-based combination treatment failure in parts of the GMS,… read more here.
Keywords: multidrug; resistant malaria; drug administration; mass drug ... See more keywords
Suspected Artesunate Resistant Malaria in South India
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DOI: 10.4103/jgid.jgid_180_16
Abstract: We report four cases of complicated malaria in Andhra Pradesh-Orissa border between July 2016 and December 2016, with apparent treatment failure with artemisinin drugs, and all showing parasitological clearance after quinine and adjuvant clindamycin therapy.… read more here.
Keywords: resistant malaria; south india; artesunate resistant; malaria south ... See more keywords