Curcumin suppresses cell proliferation and triggers apoptosis in vemurafenib‐resistant melanoma cells by downregulating the EGFR signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23450
Abstract: Melanoma is a malignant tumor with aggressive behavior. Vemurafenib, a BRAF inhibitor, is clinically used in melanoma, but resistance to melanoma cytotoxic therapies is associated with BRAF mutations. Curcumin can effectively inhibit numerous types of… read more here.
Keywords: resistant melanoma; a375 cells; vemurafenib resistant; melanoma ... See more keywords
An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.04.012
Abstract: BRAF(V600E) mutant melanomas treated with inhibitors of the BRAF and MEK kinases almost invariably develop resistance that is frequently caused by reactivation of the mitogen activated protein kinase (MAPK) pathway. To identify novel treatment options… read more here.
Keywords: inhibitor; braf mek; resistant melanoma; drug ... See more keywords
Intracellular Self-Assembly of Peptides to Induce Apoptosis against Drug-Resistant Melanoma.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c00697
Abstract: Biosynthesis has been a diverse toolbox to develop bioactive molecules and materials, especially for fabricating modified peptides and their assemblies induced by enzymes. Although desired chemical structures and nanoarchitectures have been achieved, the subsequent interferences… read more here.
Keywords: resistant melanoma; drug; drug resistant; apoptosis drug ... See more keywords
Gene Identification and Potential Drug Therapy for Drug-Resistant Melanoma with Bioinformatics and Deep Learning Technology
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/2461055
Abstract: Background Melanomas are skin malignant tumors that arise from melanocytes which are primarily treated with surgery, chemotherapy, targeted therapy, immunotherapy, radiation therapy, etc. Targeted therapy is a promising approach to treating advanced melanomas, but resistance… read more here.
Keywords: resistant melanoma; gene identification; therapy; drug resistant ... See more keywords
Abstract LB-A14: ER stress induced by 4-nerolidylcathecol (4-NC) promotes antitumor effects in BRAFi/MEKi sensitive and resistant melanoma models
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-lb-a14
Abstract: Melanoma accounts for only 4% of skin malignancies, but it has a high mortality rate. Though the specific inhibitors of MAPK pathway (BRAFi and MEKi) have revolutionized melanoma treatment, most of patients are subject to… read more here.
Keywords: melanoma; resistant melanoma; melanoma models; stress induced ... See more keywords
Abstract 4072: Class I HLA-independent lysis of immunotherapy-resistant melanoma by CD8 T cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4072
Abstract: Cancer immunotherapy with immune checkpoint blockade (ICB) has transformed the treatment of melanoma, although intrinsic or acquired resistance develops in nearly half of patients. Tumor-infiltrating CD8+ T lymphocytes (TILs) are key determinants of anti-tumor immunity… read more here.
Keywords: class hla; resistant melanoma; melanoma; class ... See more keywords
For Whom the Bell Tolls? A Toll-Like Receptor 9 Agonist's Journey from Vaccine Adjuvant to Promising Agent in Anti-PD-1-Resistant Melanoma.
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DOI: 10.1158/2159-8290.cd-21-1226
Abstract: SUMMARY Developing effective therapies in anti-PD-1-resistant melanoma is a key unmet need. The combination of pembrolizumab with the intralesional TLR9 agonist vidutolimod showed promise in this patient population with correlative analysis suggesting that patients with… read more here.
Keywords: tolls toll; resistant melanoma; bell tolls; anti resistant ... See more keywords
Changes in the Transcriptome and Chromatin Landscape in BRAFi-Resistant Melanoma Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.937831
Abstract: Metastatic and drug-resistant melanoma are leading causes of skin cancer–associated death. Mitogen-associated protein kinase (MAPK) pathway inhibitors and immunotherapies have provided substantial benefits to patients with melanoma. However, long-term therapeutic efficacy has been limited due… read more here.
Keywords: resistant melanoma; melanoma; melanoma cells; mapk pathway ... See more keywords
Deregulated FASN Expression in BRAF Inhibitor-Resistant Melanoma Cells Unveils New Targets for Drug Combinations
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DOI: 10.3390/cancers13092284
Abstract: Simple Summary Strategies to overcome resistance to targeted therapy represent a clinical need for metastatic melanoma. Altered lipid metabolism has been identified in the metabolic reprogramming associated with melanoma progression. Lipid metabolism genes such as… read more here.
Keywords: melanoma; inhibitor; resistant melanoma; braf ... See more keywords
Characterization of Vemurafenib-Resistant Melanoma Cell Lines Reveals Novel Hallmarks of Targeted Therapy Resistance
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DOI: 10.3390/ijms23179910
Abstract: Regardless of the significant improvements in treatment of melanoma, the majority of patients develop resistance whose mechanisms are still not completely understood. Hence, we generated and characterized two melanoma-derived cell lines, primary WM793B and metastatic… read more here.
Keywords: cell; resistant melanoma; melanoma; resistance ... See more keywords
3-Bromopyruvate Suppresses the Malignant Phenotype of Vemurafenib-Resistant Melanoma Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232415650
Abstract: (1) BRAF mutations are associated with high mortality and are a substantial factor in therapeutic decisions. Therapies targeting BRAF-mutated tumors, such as vemurafenib (PLX), have significantly improved the overall survival of melanoma patients. However, patient… read more here.
Keywords: plx resistant; resistant melanoma; malignant phenotype; melanoma ... See more keywords