Automated real-time detection of drug-resistant Mycobacterium tuberculosis on a lab-on-a-disc by Recombinase Polymerase Amplification.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2017.12.031
Abstract: With the emergence of multi- and extensive-drug (MDR/XDR) resistant Mycobacterium tuberculosis (M. tb), tuberculosis (TB) persists as one of the world's leading causes of death. Recently, isothermal DNA amplification methods received much attention due to… read more here.
Keywords: detection; resistant mycobacterium; real time; tuberculosis ... See more keywords
Lead compounds and key residues of ribosomal protein S1 in drug-resistant Mycobacterium tuberculosis.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.09.024
Abstract: Ribosomal protein S1 (RpsA) has been identified as a novel target of pyrazinoic acid (POA), which is the active form of pyrazinamide (PZA), in vivo. RpsA plays a crucial role in trans-translation, which is widespread… read more here.
Keywords: resistant mycobacterium; drug; drug resistant; tuberculosis ... See more keywords
Screening mutations in drug-resistant Mycobacterium tuberculosis strains in Yunnan, China.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of infection and public health"
DOI: 10.1016/j.jiph.2017.04.008
Abstract: Drug-resistant tuberculosis (DR-TB), especially multidrug-resistant tuberculosis (MDR-TB), is a serious medical and societal problem in China. The purpose of this study was to evaluate the mutation characteristics of drug-resistant Mycobacterium tuberculosis (M. tuberculosis) isolates in… read more here.
Keywords: resistant mycobacterium; drug; drug resistant; tuberculosis ... See more keywords
Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cell"
DOI: 10.1016/j.molcel.2018.08.028
Abstract: Summary Antibiotic-resistant bacterial pathogens pose an urgent healthcare threat, prompting a demand for new medicines. We report the mode of action of the natural ansamycin antibiotic kanglemycin A (KglA). KglA binds bacterial RNA polymerase at… read more here.
Keywords: rifampicin; resistant mycobacterium; rna polymerase; rifampicin resistant ... See more keywords
A highly rifampicin resistant Mycobacterium tuberculosis strain emerging in Southern Brazil.
Sign Up to like & getrecommendations! Published in 2020 at "Tuberculosis"
DOI: 10.1016/j.tube.2020.102015
Abstract: Here we described phenotypical, molecular and epidemiological features of a highly rifampicin-resistant Mycobacterium tuberculosis strain emerging in Southern Brazil, that carries an uncommon insertion of 12 nucleotides at the codon 435 in the rpoB gene.… read more here.
Keywords: resistant mycobacterium; rifampicin resistant; tuberculosis; strain ... See more keywords
Rapid and Ultrasensitive Approach for the Simultaneous Detection of Multilocus Mutations to Distinguish Rifampicin-Resistant Mycobacterium tuberculosis.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c04399
Abstract: The untested empirical medications exacerbated the development of multidrug-resistant Mycobacterium tuberculosis (MDR-TB). Here, we develop a rapid and specific method based on loop-mediated isothermal amplification and duplex-specific nuclease for distinguishing rifampicin-resistant M. tuberculosis. Three probes… read more here.
Keywords: rifampicin resistant; tuberculosis; detection; resistant mycobacterium ... See more keywords
Robust detection of point mutations involved in multidrug-resistant Mycobacterium tuberculosis in the presence of co-occurrent resistance markers
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1008518
Abstract: Tuberculosis disease is a major global public health concern and the growing prevalence of drug-resistant Mycobacterium tuberculosis is making disease control more difficult. However, the increasing application of whole-genome sequencing as a diagnostic tool is… read more here.
Keywords: resistant mycobacterium; occurrent resistance; tuberculosis; resistance ... See more keywords
Incidence, treatment, and outcomes of isoniazid mono-resistant Mycobacterium tuberculosis infections in Alberta, Canada from 2007-2017
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0229691
Abstract: Isoniazid resistant Mycobacterium tuberculosis (Hr-TB) is the most frequently encountered TB resistance phenotype in North America but limited data exist on the effectiveness of current therapeutic regimens. Ineffective treatment of Hr-TB increases patient relapse and… read more here.
Keywords: resistant mycobacterium; 2007 2017; treatment; alberta canada ... See more keywords
Metagenomics of Imported Multidrug-Resistant Mycobacterium leprae, Saudi Arabia, 2017
Sign Up to like & getrecommendations! Published in 2020 at "Emerging Infectious Diseases"
DOI: 10.3201/eid2603.190661
Abstract: Using shotgun metagenomics, we identified an imported case of multidrug-resistant Mycobacterium leprae in a Filipino resident of Saudi Arabia in 2017. We determined the phylogenomic lineage (3K1) and identified mutations in rpoB and rrs corresponding… read more here.
Keywords: resistant mycobacterium; leprae; arabia 2017; saudi arabia ... See more keywords
Evolution of Drug-Resistant Mycobacterium tuberculosis Strains and Their Adaptation to the Human Lung Environment
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.612675
Abstract: In the last two decades, multi (MDR), extensively (XDR), extremely (XXDR) and total (TDR) drug-resistant Mycobacterium tuberculosis (M.tb) strains have emerged as a threat to public health worldwide, stressing the need to develop new tuberculosis… read more here.
Keywords: resistant mycobacterium; drug; drug resistant; environment ... See more keywords
Molecular characterization of mutations in isoniazid- and rifampicin- resistant Mycobacterium tuberculosis isolated in Thailand.
Sign Up to like & getrecommendations! Published in 2022 at "Japanese journal of infectious diseases"
DOI: 10.7883/yoken.jjid.2022.055
Abstract: Drug-resistant tuberculosis (TB) is a great challenge in TB control. The frequency and mutation characteristics can imply the efficiency of molecular tests for the rapid detection of TB drug resistance. This study examined the existence… read more here.
Keywords: mycobacterium tuberculosis; rifampicin; tuberculosis; resistance ... See more keywords