Antimicrobial‐resistant Neisseria gonorrhoeae can be targeted using inhibitors against evolutionary conservedl‐asparaginase
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30271
Abstract: The emergence of multiple drug‐resistant “super gonorrhoea” complicates the management and treatment of Neisseria gonorrhoeae infections due to the progressive accumulation of mutations in the biological targets of frontline antimicrobials. Continuous evaluation and reporting of… read more here.
Keywords: neisseria gonorrhoeae; asparaginase; antimicrobial resistant; drug ... See more keywords
Multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017
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DOI: 10.2807/1560-7917.es.2017.22.42.17-00659
Abstract: We describe a multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Denmark, 2017. Whole genome sequencing of the strain GK124 identified MSLT ST1903, NG-MAST ST1614 and all… read more here.
Keywords: neisseria gonorrhoeae; resistance; multidrug resistant; gonorrhoeae infection ... See more keywords
Molecular detection of fluoroquinolone-resistant Neisseria meningitidis by using mismatched PCR-restriction fragment length polymorphism technique
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DOI: 10.3389/fcimb.2022.911911
Abstract: Ciprofloxacin (CIP) is a commonly used antibiotic for meningococcal chemoprophylaxis, and the mutations in the quinolone resistance-determining region of gyrA are associated with CIP-resistant Neisseria meningitidis. Here, we established a mismatched PCR-restriction fragment length polymorphism… read more here.
Keywords: mismatched pcr; cip resistant; microbiology; meningitidis ... See more keywords
An optimized Factor H-Fc fusion protein against multidrug-resistant Neisseria gonorrhoeae
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.975676
Abstract: Novel therapeutics against the global threat of multidrug-resistant Neisseria gonorrhoeae are urgently needed. Gonococci evade killing by complement by binding factor H (FH), a key inhibitor of the alternative pathway. FH comprises 20 short consensus… read more here.
Keywords: neisseria gonorrhoeae; complement; multidrug; factor ... See more keywords