The combination of oral-recombinant methioninase and azacitidine arrests a chemotherapy-resistant osteosarcoma patient-derived orthotopic xenograft mouse model
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-019-03986-0
Abstract: Purpose Cancers are methionine (MET) and methylation addicted, causing them to be highly sensitive to MET restriction. The present study determined the efficacy of restricting MET with oral-recombinant methioninase (o-rMETase) and the DNA methylation inhibitor,… read more here.
Keywords: chemotherapy; combination; oral recombinant; chemotherapy resistant ... See more keywords
Niclosamide is a potential candidate for the treatment of chemo-resistant osteosarcoma
Sign Up to like & getrecommendations! Published in 2023 at "Genetics and Molecular Biology"
DOI: 10.1590/1678-4685-gmb-2022-0136
Abstract: Abstract Chemotherapy is the main treatment option for advanced osteosarcoma, which is the most common type of primary bone malignancy. However, patients develop resistance rapidly and many succumb to the disease. Niclosamide, an anthelmintic drug,… read more here.
Keywords: osteosarcoma cells; osteosarcoma; chemo resistant; treatment ... See more keywords