Auranofin and its Analogues Show Potent Antimicrobial Activity against Multidrug‐Resistant Pathogens: Structure–Activity Relationships
Sign Up to like & getrecommendations! Published in 2018 at "ChemMedChem"
DOI: 10.1002/cmdc.201800498
Abstract: Due to the so‐called “antibiotic resistance crisis” new antibacterial agents are urgently sought to treat multidrug‐resistant pathogens. A group of gold‐ or silver‐based complexes, of general formula [M(PEt3)X] (with M=Au or Ag, and X=Cl, Br… read more here.
Keywords: activity relationships; resistant pathogens; structure activity; multidrug resistant ... See more keywords
[New antibiotics for severe infections due to multidrug-resistant pathogens : Definitive treatment and escalation].
Sign Up to like & getrecommendations! Published in 2019 at "Der Anaesthesist"
DOI: 10.1007/s00101-019-00646-z
Abstract: Multidrug-resistant pathogens often lead to treatment failure of antimicrobial regimens. After a period of imbalance between the occurrence/spread of resistance mechanisms and the development of new substances, some new substances have meanwhile been approved and… read more here.
Keywords: treatment; new substances; new antibiotics; resistant pathogens ... See more keywords
Postoperative infectious complications caused by multidrug-resistant pathogens in patients undergoing major hepatectomy with extrahepatic bile duct resection.
Sign Up to like & getrecommendations! Published in 2020 at "Surgery"
DOI: 10.1016/j.surg.2020.02.015
Abstract: BACKGROUND Few reports have addressed postoperative infectious complications caused by multidrug-resistant pathogens. The aim of this study was to review the surgical outcomes of patients undergoing major hepatectomy with extrahepatic bile duct resection and to… read more here.
Keywords: complications caused; postoperative infectious; resistant pathogens; multidrug resistant ... See more keywords
Rapid kill assessment of an N-arylated NH125 analogue against drug-resistant microorganisms.
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DOI: 10.1039/c8md00613j
Abstract: While a number of disinfection techniques are employed in healthcare units, the eradication of drug-resistant microorganisms remains a challenge. We recently reported N-arylated NH125 analogue 1, which demonstrated potent biofilm eradication and antibacterial activities against… read more here.
Keywords: drug resistant; drug; nh125 analogue; resistant pathogens ... See more keywords
Green synthesised zinc oxide nanostructures through Periploca aphylla extract shows tremendous antibacterial potential against multidrug resistant pathogens.
Sign Up to like & getrecommendations! Published in 2017 at "IET nanobiotechnology"
DOI: 10.1049/iet-nbt.2016.0238
Abstract: To grapple with multidrug resistant bacterial infections, implementations of antibacterial nanomedicines have gained prime attention of the researchers across the globe. Nowadays, zinc oxide (ZnO) at nano-scale has emerged as a promising antibacterial therapeutic agent.… read more here.
Keywords: microscopy; zno; zinc oxide; resistant pathogens ... See more keywords
Antimicrobial peptides as promising antibiotic adjuvants to combat drug-resistant pathogens.
Sign Up to like & getrecommendations! Published in 2023 at "Critical reviews in microbiology"
DOI: 10.1080/1040841x.2023.2186215
Abstract: The widespread antimicrobial resistance (AMR) calls for the development of new antimicrobial strategies. Antibiotic adjuvant rescues antibiotic activity and increases the life span of the antibiotics, representing a more productive, timely, and cost-effective strategy in… read more here.
Keywords: antimicrobial peptides; resistance; drug resistant; antibiotic adjuvants ... See more keywords
Automated detection of hospital outbreaks of multi-drug resistant pathogens in one Italian region
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Anti-infective Therapy"
DOI: 10.1080/14787210.2022.2098115
Abstract: ABSTRACT Background Automated tools for antimicrobial resistance surveillance are critical for improving detection of drug-resistant organisms and informing prevention and control interventions. In this study, the WHONET-SaTScan software was used at a multihospital level in… read more here.
Keywords: resistant pathogens; hospital outbreaks; detection; drug resistant ... See more keywords
Macrocyclic polyketides with siderophore mode of action from marine heterotrophic Shewanella algae: Prospective anti‐infective leads attenuate drug‐resistant pathogens
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Applied Microbiology"
DOI: 10.1111/jam.14875
Abstract: Biotechnological and chemical characterization of previously undescribed homologous siderophore‐type macrocyclic polyketides from heterotrophic Shewanella algae Microbial Type Culture Collection (MTCC) 12715 affiliated with Rhodophycean macroalga Hypnea valentiae of marine origin, with significant anti‐infective potential against… read more here.
Keywords: shewanella algae; anti infective; drug resistant; heterotrophic shewanella ... See more keywords
Regional differences in antibiotic‐resistant pathogens in patients with pneumonia: Implications for clinicians
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DOI: 10.1111/resp.13135
Abstract: Antibiotic resistance is of great concern for both infection control and the treatment of infectious diseases. Previous studies reported that the occurrence of drug‐resistant pathogens (DRPs)—for instance, methicillin‐resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa and extended‐spectrum… read more here.
Keywords: risk; community; risk factors; resistant pathogens ... See more keywords
Loci Encoding Compounds Potentially Active against Drug-Resistant Pathogens amidst a Decreasing Pool of Novel Antibiotics
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DOI: 10.1128/aem.01438-19
Abstract: Carbapenem-resistant P. aeruginosa is difficult to treat and has been deemed by the World Health Organization as a priority one pathogen for which antibiotics are most urgently needed. Although metagenomics and bioinformatic studies suggest that… read more here.
Keywords: aeruginosa; resistant pathogens; mdr; carbapenem resistant ... See more keywords
Prevalence of Multidrug-Resistant Pathogens Causing Bloodstream Infections in an Intensive Care Unit
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DOI: 10.2147/idr.s383285
Abstract: Introduction Bloodstream infections are the most severe infections that cause the highest mortality rate, especially in patients admitted to the intensive care unit (ICU). In this study, we aimed to analyze the distribution, resistance patterns… read more here.
Keywords: intensive care; bloodstream infections; prevalence; care unit ... See more keywords