CRISPR-Cas9 and CRISPR-Assisted Cytidine Deaminase Enable Precise and Efficient Genome Editing in Klebsiella pneumoniae
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DOI: 10.1128/aem.01834-18
Abstract: Genetics is a key means to study bacterial physiology. However, the highly desirable scarless genetic manipulation is often time-consuming and laborious for the major human pathogen K. pneumoniae. We developed a CRISPR-Cas9-mediated genome-editing method and… read more here.
Keywords: genome editing; pneumoniae; physiology; resistant pneumoniae ... See more keywords
Novel antimicrobial strategy: native postbiotics synergize with antibiotics to overcome resistance in Klebsiella pneumoniae
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DOI: 10.1186/s12866-025-04474-7
Abstract: The alarming rise of antimicrobial resistance (AMR), especially in Klebsiella pneumoniae, demands urgent development of novel therapeutic strategies. Recently, probiotics and their metabolites, known as postbiotics, have gained attention due to their potential to enhance… read more here.
Keywords: resistance; klebsiella pneumoniae; pneumoniae; resistant pneumoniae ... See more keywords
A single-center retrospective study of the molecular epidemiological characteristics of different Klebsiella pneumoniae infections in northern China
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DOI: 10.21037/jtd-24-1148
Abstract: Background Klebsiella pneumoniae (K. pneumoniae) is an opportunistic pathogen that can cause multiple life-threatening infections. Recently, there has been an upward trend in carbapenem-resistant K. pneumoniae infections in China. This epidemiological trend needs to be… read more here.
Keywords: resistance; klebsiella pneumoniae; pneumoniae; resistant pneumoniae ... See more keywords
Characterization of Hypervirulent and Carbapenem-Resistant K. pneumoniae Isolated from Neurological Patients
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DOI: 10.2147/idr.s392947
Abstract: Background Patients with neurological disorders were easier to develop severe intracranial infections caused by hypervirulent and carbapenem-resistant K. pneumoniae, leading to a distressing clinical outcome. In this study, eight hv-CRKP were isolated from neurological patients,… read more here.
Keywords: st11 kl64; carbapenem resistant; resistant pneumoniae; neurological patients ... See more keywords
Topical adjunctive treatment with flagellin augments pulmonary neutrophil responses and reduces bacterial dissemination in multidrug-resistant K. pneumoniae infection
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DOI: 10.3389/fimmu.2024.1450486
Abstract: Objective Antimicrobial resistance is an emerging problem and multi-drug resistant (MDR) Klebsiella pneumoniae (K. pneumoniae) represents an enormous risk of failing therapy in hospital-acquired pneumonia. The current study aimed to determine the immunomodulatory effect of… read more here.
Keywords: treatment; pneumoniae; resistant pneumoniae; flagellin ... See more keywords
Carmofur Exhibits Antimicrobial Activity Against Streptococcus pneumoniae
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DOI: 10.3390/antibiotics14030231
Abstract: Background/Objectives: Streptococcus pneumoniae (S. pneumoniae) is a major pathogen causing severe infectious diseases, with an escalating issue of antimicrobial resistance that threatens the efficacy of existing antibiotics. Given the challenges in developing traditional antibiotics, drug… read more here.
Keywords: pneumoniae; resistant pneumoniae; multidrug resistant; carmofur ... See more keywords