Resistant starch from black rice, Oryza sativa L. var. ameliorates renal inflammation, fibrosis and injury in insulin resistant rats
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7675
Abstract: It has recently been reported that black rice (BR) extract has anti‐obesity, anti‐diabetic, and anti‐osteoporosis effects. It has been shown to reduce obese‐related kidney dysfunction in animal models. This study aimed to investigate the effect… read more here.
Keywords: insulin resistant; renal inflammation; resistant rats; injury ... See more keywords
The renoprotective effect of glycyrrhizic acid in insulin-resistant rats exposed to aluminum involves the inhibition of TLR4/NF-κB signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Naunyn-Schmiedeberg's archives of pharmacology"
DOI: 10.1007/s00210-020-02012-y
Abstract: Aluminum is well recognized as a nephrotoxic agent. Its hazardous effects arise from the high risk of daily exposure. The consumption of fructose also represents a critical health issue that might negatively impact different organs,… read more here.
Keywords: tlr4 signaling; resistant rats; signaling pathway; glycyrrhizic acid ... See more keywords
Cocaine and desipramine elicit distinct striatal noradrenergic and behavioral responses in selectively bred obesity-resistant and obesity-prone rats
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.11.009
Abstract: HighlightsSystemic cocaine administration increases striatal norepinephrine in obesity‐prone rats.Striatal blockade of norepinephrine transporter via desipramine retrodialysis does not increase striatal norepinephrine levels in obesity‐prone rats.Systemic desipramine treatment leads to decreases in locomotor activity in obesity‐prone… read more here.
Keywords: resistant rats; prone rats; obesity prone; obesity resistant ... See more keywords
Activation of adenosine receptors modulates the efflux transporters in brain capillaries and restores the anticonvulsant effect of carbamazepine in carbamazepine resistant rats developed by window-pentylenetetrazole kindling
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research"
DOI: 10.1016/j.brainres.2019.146516
Abstract: Up-regulation of efflux transporters in brain capillaries may lead to the decreased therapeutic efficacy of antiepileptic drugs in patients with Drug Resistant Epilepsy. Adenosine receptor activation in brain capillaries can modulate blood-brain barrier permeability by… read more here.
Keywords: resistant rats; brain capillaries; activation; adenosine ... See more keywords
Eating 'junk-food' has opposite effects on intrinsic excitability of nucleus accumbens core neurons in obesity-susceptible vs. -resistant rats.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of neurophysiology"
DOI: 10.1152/jn.00361.2019
Abstract: The nucleus accumbens (NAc) plays critical roles in motivated behaviors, including food-seeking and feeding. Differences in NAc function contribute to over-eating that drives obesity, but the underlying mechanisms are poorly understood. In addition, there is… read more here.
Keywords: junk food; obesity; excitability; resistant rats ... See more keywords
α-Lipoic Acid Strengthens the Antioxidant Barrier and Reduces Oxidative, Nitrosative, and Glycative Damage, as well as Inhibits Inflammation and Apoptosis in the Hypothalamus but Not in the Cerebral Cortex of Insulin-Resistant Rats
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DOI: 10.1155/2022/7450514
Abstract: The research determined the role of α-lipoic acid (ALA) in reducing the brain manifestations of insulin resistance. The mechanism of ALA action is mainly based on its ability to “scavenge” oxygen free radicals and stimulate… read more here.
Keywords: lipoic acid; insulin; resistant rats; apoptosis ... See more keywords
Eslicarbazepine, but Not Lamotrigine or Ranolazine, Shows Anticonvulsant Efficacy in Carbamazepine-Resistant Rats Developed by Window-Pentylenetetrazole Kindling
Sign Up to like & getrecommendations! Published in 2022 at "Brain Sciences"
DOI: 10.3390/brainsci12050629
Abstract: Approximately 30% of epileptic patients develop Drug-Resistant Epilepsy. Based on evidence that shows a loss of efficacy in some sodium channel blocker antiseizure drugs in epilepsy, we focus our study on assessing the anticonvulsant efficacy… read more here.
Keywords: window pentylenetetrazole; anticonvulsant efficacy; ranolazine; sodium channel ... See more keywords