Efficacy of clozapine for long‐stay patients with treatment‐resistant schizophrenia: 4‐year observational study
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DOI: 10.1002/npr2.12244
Abstract: Supporting patients upon discharge following prolonged hospitalization in private psychiatric hospitals in Japan have long been an issue. This study evaluated the efficacy of clozapine in treating long‐stay patients with treatment‐resistant schizophrenia to reduce the… read more here.
Keywords: resistant schizophrenia; efficacy clozapine; stay patients; treatment resistant ... See more keywords
Case Report: Successful Use of the Combination of Electroconvulsive Therapy and Clozapine in Treating Treatment-Resistant Schizophrenia and Catatonia in an Adult with Intellectual Disability
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DOI: 10.1007/s10803-018-3589-7
Abstract: There is paucity of empirical data regarding the use of either clozapine or electroconvulsive therapy (ECT) in the acute phase and maintenance treatment of schizophrenia in adults with intellectual disability. Herein we report the successful… read more here.
Keywords: combination; schizophrenia; treatment resistant; clozapine ... See more keywords
ECT versus Sham for clozapine-resistant schizophrenia: A secondary analysis of a pilot study based on PANSS-30 individual items
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DOI: 10.1016/j.brs.2020.08.008
Abstract: Approximately 60% of patients with treatment-resistant schizophrenia (TRS) do not respond to a trial of clozapine [1]. This is termed clozapine-resistant schizophrenia (CRS). A recent metanalysis showed that clozapine augmentation with ECT is efficacious for… read more here.
Keywords: clozapine resistant; schizophrenia; clozapine; resistant schizophrenia ... See more keywords
Ultra-resistant schizophrenia and potentiation strategies
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DOI: 10.1016/j.eurpsy.2017.01.1639
Abstract: Introduction Treatment resistance to clozapine is estimated at 40–70% of the treated population. Several clozapine potentiation strategies have come into clinical practice although often without evidence-based support. Objective The aim of our work was to… read more here.
Keywords: schizophrenia; resistant schizophrenia; ultra resistant; potentiation strategies ... See more keywords
ECT augmentation of clozapine for clozapine-resistant schizophrenia: A meta-analysis of randomized controlled trials.
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DOI: 10.1016/j.jpsychires.2018.08.002
Abstract: Treatment-resistant schizophrenia (TRS) is common and debilitating. A subgroup of patients even has clozapine-resistant schizophrenia (CRS). We aimed to evaluate the efficacy and safety of electroconvulsive therapy (ECT) augmentation of clozapine for CRS. Systematic literature… read more here.
Keywords: clozapine; resistant schizophrenia; augmentation clozapine; ect augmentation ... See more keywords
Oxytocin system dysfunction in patients with treatment-resistant schizophrenia: Alterations of blood oxytocin levels and effect of a genetic variant of OXTR.
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DOI: 10.1016/j.jpsychires.2021.03.053
Abstract: Treatment-resistant schizophrenia (TRS) has a quite complex pathophysiology that includes not only severe positive symptoms but also other symptom domains. Much attention has been devoted to the overlapping psychological and biological profiles of schizophrenia and… read more here.
Keywords: resistant schizophrenia; treatment resistant; system dysfunction; oxytocin system ... See more keywords
Treatment resistant schizophrenia: Clinical, biological, and therapeutic perspectives
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DOI: 10.1016/j.nbd.2018.08.016
Abstract: Treatment resistant schizophrenia (TRS) refers to the significant proportion of schizophrenia patients who continue to have symptoms and poor outcomes despite treatment. While many definitions of TRS include failure of two different antipsychotics as a… read more here.
Keywords: schizophrenia; treatment resistant; resistant schizophrenia; treatment ... See more keywords
Clozapine tolerability in Treatment Resistant Schizophrenia: exploring the role of sex
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DOI: 10.1016/j.psychres.2020.113698
Abstract: Clozapine is the only evidence-based drug indicated for Treatment Resistant Schizophrenia but it is largely underprescribed, partially due to its life-threatening adverse effects (AEs). However, clozapine treatment is burdened by other common AEs as constipation,… read more here.
Keywords: treatment resistant; resistant schizophrenia; treatment; sex ... See more keywords
Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine
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DOI: 10.1016/j.schres.2016.10.012
Abstract: Schizophrenia is a chronic psychiatric disorder with complex genetic and environmental origins. While many antipsychotics have been demonstrated as effective in the treatment of schizophrenia, a substantial number of schizophrenia patients are partially or fully… read more here.
Keywords: schizophrenia; treatment resistant; monozygotic twin; ips cells ... See more keywords
A symptom combination predicting treatment-resistant schizophrenia – A strategy for real-world clinical practice
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DOI: 10.1016/j.schres.2020.01.002
Abstract: Early identification of symptoms that can predict treatment-resistant schizophrenia (TRS) could help clinicians to avoid delays in clozapine therapy. This study aims to investigate symptom patterns that could predict TRS using a discovery/replication study design.… read more here.
Keywords: combination; schizophrenia; treatment resistant; clinical practice ... See more keywords
Dopaminergic dysfunction and excitatory/inhibitory imbalance in treatment-resistant schizophrenia and novel neuromodulatory treatment
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DOI: 10.1038/s41380-022-01572-0
Abstract: Antipsychotic drugs are the mainstay in the treatment of schizophrenia. However, one-third of patients do not show adequate improvement in positive symptoms with non-clozapine antipsychotics. Additionally, approximately half of them show poor response to clozapine,… read more here.
Keywords: treatment; resistant schizophrenia; dopaminergic dysfunction; treatment resistant ... See more keywords