Bacterial Toxin‐Triggered Release of Antibiotics from Capsosomes Protects a Fly Model from Lethal Methicillin‐Resistant Staphylococcus aureus (MRSA) Infection
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DOI: 10.1002/adhm.202200036
Abstract: Antibiotic resistance is a severe global health threat and hence demands rapid action to develop novel therapies, including microscale drug delivery systems. Herein, a hierarchical microparticle system is developed to achieve bacteria‐activated single‐ and dual‐antibiotic… read more here.
Keywords: methicillin resistant; staphylococcus aureus; aureus mrsa; mrsa infection ... See more keywords
Biomimetic Bacteriophage‐Like Particles Formed from Probiotic Extracts and NO Donors for Eradicating Multidrug‐Resistant Staphylococcus aureus
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DOI: 10.1002/adma.202206134
Abstract: Effectively clearing multidrug‐resistant bacteria through nonantibiotic treatments is crucial for the recovery of infected tissues in favorable biological environments. Herein, a thermally responsive donor of cell‐messenger nitric oxide (NO) is combined with extracts of food‐grade… read more here.
Keywords: like particles; multidrug; staphylococcus aureus; multidrug resistant ... See more keywords
Photolysis of Staphyloxanthin in Methicillin‐Resistant Staphylococcus aureus Potentiates Killing by Reactive Oxygen Species
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DOI: 10.1002/advs.201900030
Abstract: Abstract Confronted with the severe situation that the pace of resistance acquisition is faster than the clinical introduction of new antibiotics, health organizations are calling for effective approaches to combat methicillin‐resistant Staphylococcus aureus (MRSA) infections.… read more here.
Keywords: aureus; resistant staphylococcus; photolysis staphyloxanthin; methicillin resistant ... See more keywords
Expanding the spectrum of antibiotics capable of killing multi-drug resistant Staphylococcus aureus and Pseudomonas aeruginosa.
Sign Up to like & getrecommendations! Published in 2020 at "ChemMedChem"
DOI: 10.1002/cmdc.202000239
Abstract: Infections from antibiotic resistant Staphylococcus aureus and Pseudomonas aeruginosa are a serious threat because reduced antibiotic efficacy complicates treatment decisions and prolongs the disease state in many patients. To expand the arsenal of treatments against… read more here.
Keywords: staphylococcus aureus; pseudomonas aeruginosa; resistant staphylococcus; drug ... See more keywords
Molecular epidemiology and virulence factors of methicillin‐resistant Staphylococcus aureus isolated from patients with bacteremia
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.23077
Abstract: The various virulence factors of methicillin‐resistant Staphylococcus aureus bacteremia (MRSAB) are associated with a high mortality rate worldwide. Further studies are warranted to confirm the significant relationship between the strains and virulence genes. Here, we… read more here.
Keywords: virulence; resistant staphylococcus; virulence factors; methicillin resistant ... See more keywords
Infection Microenvironment-Sensitive Photothermal Nanotherapeutic Platform to Inhibit Methicillin-Resistant Staphylococcus aureus Infection.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202200430
Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) can induce multiple inflammations. The biofilm formed by MRSA is resistant to a variety of antibiotics and is extremely difficult to cure, which seriously threatens human health. Herein, a nanoparticle encapsulating… read more here.
Keywords: methicillin resistant; infection; staphylococcus aureus; biofilm ... See more keywords
The mesenchymal stromal cell secretome impairs methicillin‐resistant Staphylococcus aureus biofilms via cysteine protease activity in the equine model
Sign Up to like & getrecommendations! Published in 2020 at "Stem Cells Translational Medicine"
DOI: 10.1002/sctm.19-0333
Abstract: Mesenchymal stromal cells (MSCs) from various species, such as humans, mice, and horses, were recently found to effectively inhibit the growth of various bacteria associated with chronic infections, such as nonhealing cutaneous wounds, via secretion… read more here.
Keywords: staphylococcus; mesenchymal stromal; aureus; resistant staphylococcus ... See more keywords
Toxin-Enabled "On-Demand" Liposomes for Enhanced Phototherapy to Treat and Protect against Methicillin-Resistant Staphylococcus aureus Infection.
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DOI: 10.1002/smll.202203292
Abstract: An effective therapeutic strategy against methicillin-resistant Staphylococcus aureus (MRSA) that does not promote further drug resistance is highly desirable. While phototherapies have demonstrated considerable promise, their application toward bacterial infections can be limited by negative… read more here.
Keywords: methicillin resistant; infection; staphylococcus aureus; demand ... See more keywords
Distribution and Antibiotics Resistance Pattern of Community-Acquired Methicillin-Resistance Staphylococcus aureus in Southwestern Nigeria.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/5584_2021_658
Abstract: BACKGROUND Methicillin-resistant Staphylococcus aureus is a global public health challenge and there is a continuous increase in community-acquired infections among people in different geographical location. We sought the distribution and antibiotics pattern of community-acquired methicillin-resistant… read more here.
Keywords: staphylococcus; staphylococcus aureus; resistant staphylococcus; methicillin resistant ... See more keywords
Characterization of Antibiotic Resistance and Virulence Traits Present in Clinical Methicillin-Resistant Staphylococcus aureus Isolates.
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DOI: 10.1007/s00284-021-02477-x
Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) is a notorious superbug which poses serious health threats to humanity. The severity of the infections depends on the prevalence of virulence factors and antibiotic resistance. In this study, attempts have… read more here.
Keywords: staphylococcus aureus; virulence; resistant staphylococcus; methicillin resistant ... See more keywords
Comparison of the effect of teicoplanin and vancomycin on experimental methicillin-resistant staphylococcus aureus keratitis
Sign Up to like & getrecommendations! Published in 2021 at "International Ophthalmology"
DOI: 10.1007/s10792-021-01696-2
Abstract: To evaluate the early efficacy and safety of intrastromal injection of teicoplanin as the alternative treatment for the methicillin-resistant Staphylococcus aureus (MRSA) keratitis by comparing it with vancomycin. Twenty-four eyes of 24 New Zealand white… read more here.
Keywords: vancomycin; treatment; resistant staphylococcus; methicillin resistant ... See more keywords