The pncA gene mutations of Mycobacterium tuberculosis in multidrug-resistant tuberculosis.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2278
Abstract: The pncA gene encodes Pyrazinamidase enzyme which converts drug pyrazinamide to active form Pyrazinoic acid but mutations in this gene can prevent enzyme activity which leads to pyrazinamide resistance. The cross-sectional study was carried out… read more here.
Keywords: pnca gene; tuberculosis; multidrug resistant; gene ... See more keywords
Outcomes of multidrug-resistant tuberculosis in Zambia: a cohort analysis
Sign Up to like & getrecommendations! Published in 2017 at "Infection"
DOI: 10.1007/s15010-017-1054-8
Abstract: PurposeThe purpose of this study was to establish a baseline for measuring the impact of the programmatic management of drug-resistant TB program by following up on outcomes of all patients diagnosed with multidrug-resistant tuberculosis in… read more here.
Keywords: zambia; tuberculosis zambia; treatment; multidrug resistant ... See more keywords
Barriers to Smoking Cessation Among Drug-Resistant Tuberculosis Patients in South Africa.
Sign Up to like & getrecommendations! Published in 2017 at "Annals of global health"
DOI: 10.1016/j.aogh.2017.05.007
Abstract: BACKGROUND Drug-resistant tuberculosis (DR-TB) remains a significant cause of morbidity and mortality. The long-term health effects of smoking and the risk of adverse TB outcomes, including increased periods of infectiousness, have been reported among DR-TB… read more here.
Keywords: south africa; cessation among; drug resistant; smoking cessation ... See more keywords
Review of automated DNA extraction systems for sequencing-based solutions for drug-resistant tuberculosis detection.
Sign Up to like & getrecommendations! Published in 2020 at "Diagnostic microbiology and infectious disease"
DOI: 10.1016/j.diagmicrobio.2020.115096
Abstract: Robust clinical specimen nucleic acid extraction instrumentation and methods are critical to the performance of downstream molecular diagnostics for the diagnosis of drug-resistant tuberculosis (DR-TB). Currently, there is a high level of interest in sequencing-based… read more here.
Keywords: extraction; based solutions; drug resistant; sequencing based ... See more keywords
WHO 2018 treatment guidelines for rifampicin-resistant tuberculosis: uncertainty, potential risks and the way forward.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2019.10.003
Abstract: The 2018 World Health Organization (WHO) treatment guidelines for multidrug-/rifampicin-resistant tuberculosis (MDR/RR-TB) give preference to all-oral long regimens for 18-20 months. The document strongly recommends combining bedaquiline, levofloxacin (or moxifloxacin) and linezolid, supplemented by cycloserine… read more here.
Keywords: mdr; treatment; rifampicin resistant; tuberculosis ... See more keywords
Psychometric evaluation of a new drug-resistant tuberculosis stigma scale.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of clinical epidemiology"
DOI: 10.1016/j.jclinepi.2021.01.007
Abstract: OBJECTIVE Stigma contributes to diagnostic delay, disease concealment and reduced wellbeing for people with multidrug-resistant tuberculosis (MDR-TB) and their communities. Despite the negative effects of stigma, there are no scales to measure stigma in people… read more here.
Keywords: stigma scale; resistant tuberculosis; stigma; people mdr ... See more keywords
Drug resistant Skeletal Tuberculosis in a tertiary care centre in South India.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of clinical orthopaedics and trauma"
DOI: 10.1016/j.jcot.2017.12.009
Abstract: Back ground Drug resistant tuberculosis is alarmingly on the rise especially in developing countries. Skeletal tuberculosis accounts up to 10% of all extra pulmonary tuberculosis. World Health Organisation (WHO) has not formulated guidelines for the… read more here.
Keywords: resistant skeletal; skeletal tuberculosis; drug; drug resistant ... See more keywords
Drug resistance detection and mutation patterns of multidrug resistant tuberculosis strains from children in Delhi
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Epidemiology and Global Health"
DOI: 10.1016/j.jegh.2016.12.003
Abstract: A total of 312 sputum samples from pediatric patients presumptive of multidrug resistant tuberculosis were tested for the detection of drug resistance using the GenoTypeMTBDRplus assay. A total of 193 (61.8%) patients were smear positive… read more here.
Keywords: drug resistance; tuberculosis; multidrug resistant; resistant tuberculosis ... See more keywords
A retrospective cohort study of isoniazid-resistant tuberculosis treatment outcomes and isoniazid resistance-associated mutations in eastern China from 2013 to 2018.
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DOI: 10.1016/j.jgar.2020.07.012
Abstract: BACKGROUND The current situation of rifampicin-susceptible, isoniazid-resistant tuberculosis (Hr-TB) and associated genetic factors were not clear in China. METHODS A retrospective cohort study was conducted from 2013 to 2018 in Jiangsu province. The phenotypic Hr-TB… read more here.
Keywords: resistant tuberculosis; retrospective cohort; isoniazid resistant; unfavorable outcomes ... See more keywords
Multi-drug resistant tuberculosis, ten years later
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DOI: 10.1016/j.medcle.2020.08.009
Abstract: Drug-resistant tuberculosis, especially those with resistance to rifampicin (RR-TB), has become one of the main obstacles to achieving the dream of eradicating tuberculosis. Furthermore, it is necessary to combine three or four different drugs in… read more here.
Keywords: resistant tuberculosis; tuberculosis ten; drug resistant; tuberculosis ... See more keywords
Expression profiling of TRIM gene family reveals potential diagnostic biomarkers for rifampicin-resistant tuberculosis.
Sign Up to like & getrecommendations! Published in 2021 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2021.104916
Abstract: The epidemic of pulmonary tuberculosis (TB), especially rifampin-resistant tuberculosis (RR-TB) presents a major challenge for TB control today. However, there is a lack of reliable and specific biomarkers for the early diagnosis of RR-TB. We… read more here.
Keywords: gene family; tuberculosis; expression profiling; profiling trim ... See more keywords