Red-Light-Responsive Metallopolymer Nanocarriers with Conjugated and Encapsulated Drugs for Phototherapy Against Multidrug-Resistant Tumors.
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DOI: 10.1002/smll.202201672
Abstract: It is challenging to treat multidrug-resistant tumors because such tumors are resistant to a broad spectrum of structurally and functionally unrelated drugs. Herein, treatment of multidrug-resistant tumors using red-light-responsive metallopolymer nanocarriers that are conjugated with… read more here.
Keywords: light responsive; multidrug; multidrug resistant; red light ... See more keywords
Coadministration with bendamustine restores the antitumor activity of obinutuzumab in obinutuzumab-resistant tumors
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DOI: 10.1007/s12185-022-03320-0
Abstract: The glycoengineered, humanized anti-CD20 antibody obinutuzumab is indicated for previously untreated or relapsed/refractory CD20-positive follicular lymphoma (FL). However, the effectiveness of obinutuzumab retreatment in relapsed/refractory FL after prior obinutuzumab-containing therapy is unclear. To address this… read more here.
Keywords: obinutuzumab resistant; antitumor activity; day; resistant tumors ... See more keywords
Baseline and post-treatment biomarkers of resistance to anti-PD-1 therapy in acral and mucosal melanoma: an observational study
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DOI: 10.1136/jitc-2022-004879
Abstract: Background Immunotherapies targeting programmed cell death-1 (PD-1) and its ligands have improved clinical outcomes for advanced melanoma. However, many tumors exhibit primary resistance or acquire secondary resistance after an initial positive response. The mechanisms of… read more here.
Keywords: baseline; expression; resistant tumors; treatment ... See more keywords
Abstract 2701: Proteogenomic analysis of endoscopy biopsy identifies alterations in apoptotic pathways in trastuzumab-resistant gastric cancers
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DOI: 10.1158/1538-7445.am2018-2701
Abstract: Although the combination of trastuzumab with cisplatin and fluoropyrimidine is standard therapy for metastatic HER2-positive gastric cancers, predictive biomarkers for this therapy need to be further refined. Given the multifactorial nature of clinical trastuzumab resistance,… read more here.
Keywords: biopsy; gastric cancers; resistant tumors; alterations apoptotic ... See more keywords
Targeted Self-Emulsifying Drug Delivery Systems to Restore Docetaxel Sensitivity in Resistant Tumors
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DOI: 10.3390/pharmaceutics14020292
Abstract: The use of chemotherapeutic agents such as docetaxel (DTX) in anticancer therapy is often correlated to side effects and the occurrence of drug resistance, which substantially impair the efficacy of the drug. Here, we demonstrate… read more here.
Keywords: self emulsifying; delivery systems; emulsifying drug; drug delivery ... See more keywords