Single-Particle Resolution of Copper-Associated Annular α-Synuclein Oligomers Reveals Potential Therapeutic Targets of Neurodegeneration
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DOI: 10.1021/acschemneuro.2c00021
Abstract: Metal ions stabilize protein–protein interactions and can modulate protein aggregation. Here, using liquid-based atomic force microscopy and molecular dynamics simulations, we study the concentration-dependent effect of Cu2+ ions on the aggregation pathway of α-synuclein (α-Syn)… read more here.
Keywords: particle resolution; resolution copper; cu2 ions; microscopy ... See more keywords