Retrospective analysis for valproate screening targets with liquid chromatography-high resolution mass spectrometry with positive electrospray ionization: An omics-based approach.
Sign Up to like & getrecommendations! Published in 2019 at "Drug testing and analysis"
DOI: 10.1002/dta.2543
Abstract: Liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS) is an important analytical tool in the systematic toxicological analysis performed in forensic toxicology. However, some important compounds, such as the antiepileptic drug valproate (valproic acid; VPA),… read more here.
Keywords: high resolution; analysis; liquid chromatography; resolution mass ... See more keywords
Update on Metabolism of Abemaciclib: In Silico, In vitro and In vivo Metabolite Identification and Characterization using High Resolution Mass spectrometry.
Sign Up to like & getrecommendations! Published in 2019 at "Drug testing and analysis"
DOI: 10.1002/dta.2725
Abstract: Abemaciclib is approved by US Food and Drug Administration in 2015 to have an advanced treatment for metastatic breast cancer. Identification and characterization of limited numbers of abemaciclib metabolites have been reported in the literature.… read more here.
Keywords: high resolution; vitro vivo; mass; using high ... See more keywords
Chemical profiling of Zilong Jin tablets using ultra high performance liquid chromatography-quadrupole/orbitrap high resolution mass spectrometry.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of separation science"
DOI: 10.1002/jssc.202100310
Abstract: Zilongjin tablets as a traditional Chinese medicine is widely used for primary lung cancer patients with deficiency of "qi "and "blood " syndrome undergoing chemotherapy. It is a compound preparation that consists of eight herbs.… read more here.
Keywords: high resolution; mass spectrometry; mass; zilong jin ... See more keywords
Characterization and Identification of the Metabolites of Dihydromethysticin by Ultra-High Performance Liquid Chromatography Orbitrap High Resolution Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202200250
Abstract: Dihydromethysticin, a natural component from Piper methysticum Forst, has been reported to display pharmacological effects in mental disorders and some malignant tumors. However, the metabolism of this component remained unknown. The goal of this work… read more here.
Keywords: ultra high; resolution mass; high resolution; high performance ... See more keywords
The Hidden Face of Wine Polyphenol Polymerization Highlighted by High‐Resolution Mass Spectrometry
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DOI: 10.1002/open.201700044
Abstract: Abstract Polyphenols, including tannins and red anthocyanin pigments, are responsible for the color, taste, and beneficial health properties of plant‐derived foods and beverages, especially in red wines. Known compounds represent only the emerged part of… read more here.
Keywords: high resolution; wine polyphenol; mass spectrometry; mass ... See more keywords
High-Resolution Mass Spectrometry to Identify and Quantify Acetylation Protein Targets.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9434-2_1
Abstract: The dynamic nature of protein posttranslational modification (PTM) allows cells to rapidly respond to changes in their environment, such as nutrition, stress, or signaling. Lysine residues are targets for several types of modifications, including methylation,… read more here.
Keywords: protein; high resolution; acetylation; mass spectrometry ... See more keywords
In house validation of a high resolution mass spectrometry Orbitrap-based method for multiple allergen detection in a processed model food
Sign Up to like & getrecommendations! Published in 2018 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-018-0927-8
Abstract: In recent years, mass spectrometry (MS) has been establishing its role in the development of analytical methods for multiple allergen detection, but most analyses are being carried out on low-resolution mass spectrometers such as triple… read more here.
Keywords: resolution; detection; mass spectrometry; multiple allergen ... See more keywords
New insights in hemp chemical composition: a comprehensive polar lipidome characterization by combining solid phase enrichment, high-resolution mass spectrometry, and cheminformatics
Sign Up to like & getrecommendations! Published in 2019 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-019-02247-6
Abstract: The chemical composition of Cannabis sativa L. has been extensively investigated for several years; nevertheless, a detailed lipidome characterization is completely lacking in the literature. To achieve this goal, an extraction and enrichment procedure was… read more here.
Keywords: high resolution; chemical composition; composition; lipidome characterization ... See more keywords
High-resolution mass spectrometry metabolomics of grape chemical markers to reveal use of not-allowed varieties in the production of Amarone and Recioto wines
Sign Up to like & getrecommendations! Published in 2018 at "Metabolomics"
DOI: 10.1007/s11306-018-1415-z
Abstract: IntroductionGrape varieties allowed to produce Amarone della Valpolicella and Recioto DOCG wines are strictly regulated by their disciplinary of production. These are Corvina Veronese and Corvinone grapes, to a lesser extent also Rondinella can be… read more here.
Keywords: negro amaro; high resolution; use; mass spectrometry ... See more keywords
Targeted metabolomics of CSF in healthy individuals and patients with secondary progressive multiple sclerosis using high-resolution mass spectrometry
Sign Up to like & getrecommendations! Published in 2020 at "Metabolomics"
DOI: 10.1007/s11306-020-1648-5
Abstract: Introduction Standardized commercial kits enable targeted metabolomics analysis and may thus provide an attractive complement to the more explorative approaches. The kits are typically developed for triple quadrupole mass spectrometers using serum and plasma. Objectives… read more here.
Keywords: high resolution; mass spectrometry; targeted metabolomics; mass ... See more keywords
Metabolism of the new synthetic cannabinoid EG-018 in human hepatocytes by high-resolution mass spectrometry
Sign Up to like & getrecommendations! Published in 2018 at "Forensic Toxicology"
DOI: 10.1007/s11419-018-0404-2
Abstract: PurposeThe present study aims to recommend appropriate urinary marker metabolites for documenting EG-018 consumption by investigating its metabolism in human hepatocytes.MethodsFor metabolite profiling, 10 µM EG-018 was incubated in human hepatocytes for 3 h. Metabolite identification in… read more here.
Keywords: high resolution; 018 human; mass spectrometry; metabolism ... See more keywords