Retrospective analysis for valproate screening targets with liquid chromatography-high resolution mass spectrometry with positive electrospray ionization: An omics-based approach.
Sign Up to like & getrecommendations! Published in 2019 at "Drug testing and analysis"
DOI: 10.1002/dta.2543
Abstract: Liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS) is an important analytical tool in the systematic toxicological analysis performed in forensic toxicology. However, some important compounds, such as the antiepileptic drug valproate (valproic acid; VPA),… read more here.
Keywords: high resolution; analysis; liquid chromatography; resolution mass ... See more keywords
Update on Metabolism of Abemaciclib: In Silico, In vitro and In vivo Metabolite Identification and Characterization using High Resolution Mass spectrometry.
Sign Up to like & getrecommendations! Published in 2019 at "Drug testing and analysis"
DOI: 10.1002/dta.2725
Abstract: Abemaciclib is approved by US Food and Drug Administration in 2015 to have an advanced treatment for metastatic breast cancer. Identification and characterization of limited numbers of abemaciclib metabolites have been reported in the literature.… read more here.
Keywords: high resolution; vitro vivo; mass; using high ... See more keywords
Characterization of Novel Enarodustat Metabolites Using Liquid Chromatography-High Resolution Mass Spectrometry for Doping Control Purposes.
Sign Up to like & getrecommendations! Published in 2025 at "Drug testing and analysis"
DOI: 10.1002/dta.70007
Abstract: Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) represent a novel class of therapeutic substances that increase erythropoiesis. Due to their performance-enhancing effects and potential risk of abuse, these agents were added to the World Anti-Doping Agency… read more here.
Keywords: high resolution; mass spectrometry; chromatography high; enarodustat ... See more keywords
Chemical profiling of Zilong Jin tablets using ultra high performance liquid chromatography-quadrupole/orbitrap high resolution mass spectrometry.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of separation science"
DOI: 10.1002/jssc.202100310
Abstract: Zilongjin tablets as a traditional Chinese medicine is widely used for primary lung cancer patients with deficiency of "qi "and "blood " syndrome undergoing chemotherapy. It is a compound preparation that consists of eight herbs.… read more here.
Keywords: high resolution; mass spectrometry; mass; zilong jin ... See more keywords
Characterization and Identification of the Metabolites of Dihydromethysticin by Ultra-High Performance Liquid Chromatography Orbitrap High Resolution Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202200250
Abstract: Dihydromethysticin, a natural component from Piper methysticum Forst, has been reported to display pharmacological effects in mental disorders and some malignant tumors. However, the metabolism of this component remained unknown. The goal of this work… read more here.
Keywords: ultra high; resolution mass; high resolution; high performance ... See more keywords
The Hidden Face of Wine Polyphenol Polymerization Highlighted by High‐Resolution Mass Spectrometry
Sign Up to like & getrecommendations! Published in 2017 at "ChemistryOpen"
DOI: 10.1002/open.201700044
Abstract: Abstract Polyphenols, including tannins and red anthocyanin pigments, are responsible for the color, taste, and beneficial health properties of plant‐derived foods and beverages, especially in red wines. Known compounds represent only the emerged part of… read more here.
Keywords: high resolution; wine polyphenol; mass spectrometry; mass ... See more keywords
From MS1 to Structure: A Van Krevelen–DBE–Aromaticity‐Based Framework for Annotating Specialized Metabolites via High‐Resolution Mass Spectrometry
Sign Up to like & getrecommendations! Published in 2025 at "Rapid Communications in Mass Spectrometry"
DOI: 10.1002/rcm.10145
Abstract: Classifying specialized metabolites in untargeted metabolomics remains a major challenge, particularly when relying solely on high‐resolution mass spectrometry (HRMS) data at the MS1 level. Traditional approaches using Van Krevelen diagrams often lack sufficient resolution to… read more here.
Keywords: mass spectrometry; resolution mass; resolution; high resolution ... See more keywords
High-Resolution Mass Spectrometry to Identify and Quantify Acetylation Protein Targets.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9434-2_1
Abstract: The dynamic nature of protein posttranslational modification (PTM) allows cells to rapidly respond to changes in their environment, such as nutrition, stress, or signaling. Lysine residues are targets for several types of modifications, including methylation,… read more here.
Keywords: protein; high resolution; acetylation; mass spectrometry ... See more keywords
In house validation of a high resolution mass spectrometry Orbitrap-based method for multiple allergen detection in a processed model food
Sign Up to like & getrecommendations! Published in 2018 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-018-0927-8
Abstract: In recent years, mass spectrometry (MS) has been establishing its role in the development of analytical methods for multiple allergen detection, but most analyses are being carried out on low-resolution mass spectrometers such as triple… read more here.
Keywords: resolution; detection; mass spectrometry; multiple allergen ... See more keywords
New insights in hemp chemical composition: a comprehensive polar lipidome characterization by combining solid phase enrichment, high-resolution mass spectrometry, and cheminformatics
Sign Up to like & getrecommendations! Published in 2019 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-019-02247-6
Abstract: The chemical composition of Cannabis sativa L. has been extensively investigated for several years; nevertheless, a detailed lipidome characterization is completely lacking in the literature. To achieve this goal, an extraction and enrichment procedure was… read more here.
Keywords: high resolution; chemical composition; composition; lipidome characterization ... See more keywords
Handling of problematic ion chromatograms with the Automated Target Screening (ATS) workflow for unsupervised analysis of high-resolution mass spectrometry data
Sign Up to like & getrecommendations! Published in 2024 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-024-05245-5
Abstract: Liquid chromatography (LC) or gas chromatography (GC) coupled to high-resolution mass spectrometry (HRMS) is a versatile analytical method for the analysis of thousands of chemical pollutants that can be found in environmental and biological samples.… read more here.
Keywords: analysis; ats workflow; resolution mass; target screening ... See more keywords