High-resolution structure discloses the potential for allosteric regulation of mitogen-activated protein kinase kinase 7.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.09.025
Abstract: Mitogen-activated protein kinase kinase 7 (MAP2K7) regulates stress and inflammatory responses, and is an attractive drug discovery target for several diseases including arthritis and cardiac hypertrophy. Intracellular proteins such as MAP2K7 are prone to aggregation… read more here.
Keywords: resolution; kinase; activated protein; resolution structure ... See more keywords
High-resolution structure and strain comparison of infectious mammalian prions.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.08.011
Abstract: Within the extensive range of self-propagating pathologic protein aggregates of mammals, prions are the most clearly infectious (e.g., ∼109 lethal doses per milligram). The structures of such lethal assemblies of PrP molecules have been poorly… read more here.
Keywords: high resolution; prion; structure; strain ... See more keywords
Atomic-Resolution Structure of SARS-CoV-2 Nucleocapsid Protein N-Terminal Domain
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c03320
Abstract: The nucleocapsid (N) protein is one of the four structural proteins of the SARS-CoV-2 virus and plays a crucial role in viral genome organization and, hence, replication and pathogenicity. The N-terminal domain (NNTD) binds to… read more here.
Keywords: nucleocapsid protein; resolution structure; structure; terminal domain ... See more keywords
Atomic-Resolution Structure of the Protein Encoded by Gene V of fd Bacteriophage in Complex with Viral ssDNA Determined by Magic-Angle Spinning Solid-State NMR
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c09957
Abstract: F-specific filamentous phages, elongated particles with circular single-stranded DNA encased in a symmetric protein capsid, undergo an intermediate step, where thousands of homodimers of a non-structural protein, gVp, bind to newly synthesized strands of DNA,… read more here.
Keywords: resolution structure; structure; angle spinning; atomic resolution ... See more keywords
Structure of photosynthetic LH1–RC supercomplex at 1.9 Å resolution
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/s41586-018-0002-9
Abstract: Light-harvesting complex 1 (LH1) and the reaction centre (RC) form a membrane-protein supercomplex that performs the primary reactions of photosynthesis in purple photosynthetic bacteria. The structure of the LH1–RC complex can provide information on the… read more here.
Keywords: lh1 supercomplex; lh1; structure; calcium ion ... See more keywords
High-Resolution Structure-from-Motion for Quantitative Measurement of Leading-Edge Roughness
Sign Up to like & getrecommendations! Published in 2020 at "Energies"
DOI: 10.3390/en13153916
Abstract: Over time, erosion of the leading edge of wind turbine blades increases the leading-edge roughness (LER). This may reduce the aerodynamic performance of the blade and hence the annual energy production of the wind turbine.… read more here.
Keywords: resolution; high resolution; leading edge; edge roughness ... See more keywords