Spatially Resolved Metabolomics Method for Mapping the Global Molecular Landscape of Whole-Body Zebrafish (Danio rerio) Using Ambient Mass Spectrometry Imaging.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c05047
Abstract: Zebrafish (Danio rerio) represent an effective model biological material for human disease research, even for personalized precision medicine. Thus, it is necessary to fully characterize their molecular information in order to obtain a global metabolic… read more here.
Keywords: whole body; metabolomics method; spatially resolved; danio rerio ... See more keywords
Toward spatially resolved metabolomics
Sign Up to like & getrecommendations! Published in 2020 at "Nature Chemical Biology"
DOI: 10.1038/s41589-020-00650-0
Abstract: Coherent Raman imaging enables mapping of chemical features at subcellular resolution, setting the stage for tracking lipids and other metabolites in intact living systems. read more here.
Keywords: toward spatially; resolved metabolomics; biology; spatially resolved ... See more keywords
Can spatially resolved metabolomics uncover weak points in tumors?
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Proteomics"
DOI: 10.1080/14789450.2023.2176754
Abstract: The complexity and diversity derived from genetics and evolution lead to tumor heterogeneity. The spatial and temporal evolution of tumor heterogeneity during tumor development results in the dynamic reprogramming of the tumor microenvironment (TME) [1].… read more here.
Keywords: heterogeneity; mass spectrometry; spatially resolved; spatial metabolomics ... See more keywords
Microbiome and spatially resolved metabolomics analysis reveal the anticancer role of gut Akkermansia muciniphila by crosstalk with intratumoral microbiota and reprogramming tumoral metabolism in mice
Sign Up to like & getrecommendations! Published in 2023 at "Gut Microbes"
DOI: 10.1080/19490976.2023.2166700
Abstract: ABSTRACT Although gut microbiota has been linked to cancer, little is known about the crosstalk between gut- and intratumoral-microbiomes. The goal of this study was to determine whether gut Akkermansia muciniphila (Akk) is involved in… read more here.
Keywords: gut; akk; spatially resolved; microbiome ... See more keywords
Investigating the role of GLUL as a survival factor in cellular adaptation to glutamine depletion via targeted stable isotope resolved metabolomics
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.859787
Abstract: Cellular glutamine synthesis is thought to be an important resistance factor in protecting cells from nutrient deprivation and may also contribute to drug resistance. The application of ‟targeted stable isotope resolved metabolomics” allowed to directly… read more here.
Keywords: stable isotope; glutamine; resolved metabolomics; isotope resolved ... See more keywords
Molecular Pathological Diagnosis of Thyroid Tumors Using Spatially Resolved Metabolomics
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27041390
Abstract: The pathological diagnosis of benign and malignant follicular thyroid tumors remains a major challenge using the current histopathological technique. To improve diagnosis accuracy, spatially resolved metabolomics analysis based on air flow-assisted desorption electrospray ionization mass… read more here.
Keywords: thyroid; diagnosis; pathological diagnosis; thyroid tumors ... See more keywords