Concise Review: Pro-Resolving Lipid Mediators and Receptors in Stem Cell Biology.
Sign Up to like & getrecommendations! Published in 2019 at "Stem cells translational medicine"
DOI: 10.1002/sctm.19-0078
Abstract: Accumulating evidence indicates that stem cells (SCs) possess immunomodulatory, anti-inflammatory, and pro-healing properties. The mechanisms underlying these functions are being investigated with the final goal to set a solid background for the clinical use of… read more here.
Keywords: medicine; resolving lipid; pro resolving; lipid mediators ... See more keywords
Pro-resolving lipid mediator lipoxin A4 attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109201
Abstract: SUMMARY The chronic neuro-inflammatory character of multiple sclerosis (MS) suggests that the natural process to resolve inflammation is impaired. This protective process is orchestrated by specialized pro-resolving lipid mediators (SPMs), but to date, the role… read more here.
Keywords: resolving lipid; pro resolving; inflammation; cord lipidome ... See more keywords
Low levels of pro-resolving lipid mediators lipoxin-A4, resolvin-D1 and resolvin-E1 in patients with rheumatoid arthritis.
Sign Up to like & getrecommendations! Published in 2020 at "Immunology letters"
DOI: 10.1016/j.imlet.2020.08.006
Abstract: Rheumatoid arthritis (RA) is a disease in which joint inflammation is at the forefront but the whole body is affected, and prevention of inflammation is the main treatment approach. Lipoxins (LXs) and resolvins (Rvs) are… read more here.
Keywords: resolving lipid; levels pro; pro resolving; lipid mediators ... See more keywords
Pro-resolving lipid mediators as therapeutic leads for cardiovascular diseases
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2019.1599360
Abstract: ABSTRACT Introduction: Cardiovascular diseases are the leading cause of human death globally. Lipid mediators contribute to the initiation and resolution of inflammation in the pathogenesis of cardiovascular diseases. These resolving lipid mediators antagonize the effects… read more here.
Keywords: resolving lipid; lipid mediators; pro resolving; cardiovascular diseases ... See more keywords
Current experimental methods to investigate the impact of specialized pro-resolving lipid mediators on Sjögren’s syndrome
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1094278
Abstract: Sjögren’s syndrome is a chronic inflammatory autoimmune disease characterized by diminished secretory function of the exocrine glands. Although extensive investigation has been done to understand Sjögren’s syndrome, the causes of the disease are as yet… read more here.
Keywords: pro resolving; gren syndrome; specialized pro; lipid mediators ... See more keywords
Roles, Actions, and Therapeutic Potential of Specialized Pro-resolving Lipid Mediators for the Treatment of Inflammation in Cystic Fibrosis
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.00252
Abstract: Non-resolving inflammation is the main mechanism of morbidity and mortality among patients suffering from cystic fibrosis (CF), the most common life-threatening human genetic disease. Resolution of inflammation is an active process timely controlled by endogenous… read more here.
Keywords: specialized pro; cystic fibrosis; resolving lipid; pro resolving ... See more keywords
Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators—What is the Evidence so far?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.838782
Abstract: Formation of specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of arachidonic acid 12- and 15-lipoxygenating paralogues (15-LO1, ALOX15; 15-LO2, ALOX15B; 12-LO, ALOX12).… read more here.
Keywords: pro resolving; specialized pro; formation signaling; resolving lipid ... See more keywords
Specialized Pro-Resolving Lipid Mediators in Neonatal Cardiovascular Physiology and Diseases
Sign Up to like & getrecommendations! Published in 2021 at "Antioxidants"
DOI: 10.3390/antiox10060933
Abstract: Cardiovascular disease remains a leading cause of mortality worldwide. Unresolved inflammation plays a critical role in cardiovascular diseases development. Specialized Pro-Resolving Mediators (SPMs), derived from long chain polyunsaturated fatty acids (LCPUFAs), enhances the host defense,… read more here.
Keywords: specialized pro; resolving lipid; pro resolving; cardiovascular health ... See more keywords
Specialized Pro-Resolving Lipid Mediators in Cystic Fibrosis
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19102865
Abstract: In cystic fibrosis (CF), impaired airway surface hydration (ASL) and mucociliary clearance that promote chronic bacterial colonization, persistent inflammation, and progressive structural damage to the airway wall architecture are typically explained by ion transport abnormalities… read more here.
Keywords: specialized pro; cystic fibrosis; resolving lipid; fibrosis ... See more keywords
Topical Administration of a Marine Oil Rich in Pro-Resolving Lipid Mediators Accelerates Wound Healing in Diabetic db/db Mice through Angiogenesis and Macrophage Polarization
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23179918
Abstract: Impaired wound healing in patients with type 2 diabetes (DM2) is characterized by chronic inflammation, which delays wound closure. Specialized pro-resolving lipid mediators (SPMs) are bioactive molecules produced from essential polyunsaturated fatty acids (PUFAs), principally… read more here.
Keywords: wound healing; pro resolving; oil; lipid mediators ... See more keywords
Pro-Resolving Lipid Mediators in the Pathophysiology of Asthma
Sign Up to like & getrecommendations! Published in 2019 at "Medicina"
DOI: 10.3390/medicina55060284
Abstract: Asthma is one of the most important medical and social problems of our time due to the prevalence and the complexity of its treatment. Chronic inflammation that is characteristic of asthma is accompanied by bronchial… read more here.
Keywords: resolving lipid; lipid mediators; pro resolving; pathophysiology asthma ... See more keywords