Specialized pro-resolving mediators in cardiovascular diseases.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular aspects of medicine"
DOI: 10.1016/j.mam.2017.02.003
Abstract: The resolution of inflammation is a highly regulated process enacted by endogenous mediators including specialized pro-resolving lipid mediators (SPMs): the lipoxins, resolvins, protectins and maresins. SPMs activate specific cellular receptors to temper the production of… read more here.
Keywords: specialized pro; resolving mediators; pro resolving; inflammation ... See more keywords
Inflammatory and Pro-resolving Mediators in Frontotemporal Dementia and Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2019.09.008
Abstract: Chronic inflammation contributes to neuronal death in Alzheimer's disease (AD) and frontotemporal dementia (FTD). Here we evaluated inflammatory and pro-resolving mediators in AD and behavioural variant of FTD (bvFTD) patients compared with controls, since neuroinflamamtion… read more here.
Keywords: frontotemporal dementia; resolving mediators; pro resolving; inflammatory pro ... See more keywords
Specialized pro-resolving mediators in diabetes: novel therapeutic strategies.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical science"
DOI: 10.1042/cs20190067
Abstract: Diabetes mellitus (DM) is an important metabolic disorder characterized by persistent hyperglycemia resulting from inadequate production and secretion of insulin, impaired insulin action, or a combination of both. Genetic disorders and insulin receptor disorders, environmental… read more here.
Keywords: specialized pro; mediators diabetes; resolving mediators; pro resolving ... See more keywords
Receptors for pro‐resolving mediators are increased in Alzheimer's disease brain
Sign Up to like & getrecommendations! Published in 2020 at "Brain Pathology"
DOI: 10.1111/bpa.12812
Abstract: Neuroinflammation is a key element of AD pathology and conceivably a result of a disturbed resolution. Resolution of inflammation is an active process which is strictly orchestrated following the acute inflammatory response after removal of… read more here.
Keywords: resolving mediators; pro resolving; mediators increased; inflammation ... See more keywords
Identification and structure elucidation of the pro‐resolving mediators provides novel leads for resolution pharmacology
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14336
Abstract: Inflammatory diseases are a major socio‐economic burden, with the incidence of such conditions on the rise, especially in western societies. For decades, the primary treatment paradigm for many of these conditions was to develop drugs… read more here.
Keywords: resolving mediators; pro resolving; resolution pharmacology; pharmacology ... See more keywords
Specialized Pro-Resolving Mediators as Resolution Pharmacology for the Control of Pain and Itch.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of pharmacology and toxicology"
DOI: 10.1146/annurev-pharmtox-051921-084047
Abstract: Specialized pro-resolving mediators (SPMs), including resolvins, protectins, and maresins, are endogenous lipid mediators that are synthesized from omega-3 polyunsaturated fatty acids during the acute phase or resolution phase of inflammation. Synthetic SPMs possess broad safety… read more here.
Keywords: toxicology; pharmacology; pro resolving; specialized pro ... See more keywords
Aspirin modulates production of pro-inflammatory and pro-resolving mediators in endothelial cells
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0283163
Abstract: Endothelial cells synthesize biochemical signals to coordinate a response to insults, resolve inflammation and restore barrier integrity. Vascular cells release a variety of vasoactive bioactive lipid metabolites during the inflammatory response and produce pro-resolving mediators… read more here.
Keywords: inflammatory pro; endothelial cells; pro resolving; production ... See more keywords
Are specialized pro-resolving mediators promising therapeutic agents for severe bronchial asthma?
Sign Up to like & getrecommendations! Published in 2017 at "Journal of thoracic disease"
DOI: 10.21037/jtd.2017.10.116
Abstract: In Japan, although the number of patients with asthma has increased, the number of patients who die from asthma has decreased (1.2 per 100,000 patients in 2015) (1). Currently, although the majority of asthma patients… read more here.
Keywords: specialized pro; mediators promising; resolving mediators; pro resolving ... See more keywords
Could Arachidonic Acid-Derived Pro-Resolving Mediators Be a New Therapeutic Strategy for Asthma Therapy?
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.580598
Abstract: Asthma represents one of the leading chronic diseases worldwide and causes a high global burden of death and disability. In asthmatic patients, the exacerbation and chronification of the inflammatory response are often related to a… read more here.
Keywords: resolving mediators; pro resolving; 15d pgj2; arachidonic acid ... See more keywords
Role of Specialized Pro-resolving Mediators in Reducing Neuroinflammation in Neurodegenerative Disorders
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.780811
Abstract: Alzheimer’s disease (AD) and Parkinson’s disease (PD) are neurodegenerative disorders that affect millions of individuals worldwide. As incidence of these conditions increases with age, there will undoubtedly be an increased prevalence of cases in the… read more here.
Keywords: pro resolving; specialized pro; spm; neurodegenerative disorders ... See more keywords
Role of Specialized Pro-Resolving Mediators in Neuropathic Pain
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.717993
Abstract: Inflammation and neuroinflammation are critical mechanisms in the generation of neuropathic pain that is experienced in several chronic diseases. The aberrant inflammation that triggers this pathophysiologic process can be tracked down to an exacerbated immune… read more here.
Keywords: specialized pro; resolving mediators; pro resolving; inflammation ... See more keywords