Impact of statins on cellular respiration and de‐differentiation of myofibroblasts in human failing hearts
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DOI: 10.1002/ehf2.12509
Abstract: Fibroblast to myofibroblast trans‐differentiation with altered bioenergetics precedes cardiac fibrosis (CF). Either prevention of differentiation or promotion of de‐differentiation could mitigate CF‐related pathologies. We determined whether 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A (HMG‐CoA) reductase inhibitors—statins, commonly prescribed to patients… read more here.
Keywords: differentiation myofibroblasts; cellular respiration; impact statins; differentiation ... See more keywords