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   Articles with "respiratory complex" as a keyword



Docking and molecular simulations reveal a quinone binding site on the surface of respiratory complex I.

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recommendations! Published in 2022 at "FEBS letters"

DOI: 10.1002/1873-3468.14346

Abstract: The first component of the mitochondrial electron transport chain is respiratory complex I. Several high-resolution structures of complex I from different species have been resolved. However, despite these significant achievements, the mechanism of redox-coupled proton… read more here.

Keywords: surface; docking molecular; binding site; site ... See more keywords

The ins and outs of the flavin mononucleotide cofactor of respiratory complex I

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recommendations! Published in 2022 at "IUBMB Life"

DOI: 10.1002/iub.2600

Abstract: The flavin mononucleotide (FMN) cofactor of respiratory complex I occupies a key position in the electron transport chain. Here, the electrons coming from NADH start the sequence of oxidoreduction reactions, which drives the generation of… read more here.

Keywords: respiratory complex; cofactor respiratory; cofactor; ins outs ... See more keywords

Activation of respiratory Complex I from Escherichia coli studied by fluorescent probes

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recommendations! Published in 2017 at "Heliyon"

DOI: 10.1016/j.heliyon.2016.e00224

Abstract: Respiratory Complex I from E. coli may exist in two interconverting forms: resting (R) and active (A). The R/A transition of purified, solubilized Complex I occurring upon turnover was studied employing two different fluorescent probes,… read more here.

Keywords: activation respiratory; coli; respiratory complex; fluorescent probes ... See more keywords

Proton Transfer through a Charged Conduit in Respiratory Complex I: Long-Range Effects and Conformational Gating

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recommendations! Published in 2025 at "Journal of Chemical Information and Modeling"

DOI: 10.1021/acs.jcim.5c01365

Abstract: Energy coupling processes in respiratory complex I, a large redox-driven proton pump in the inner mitochondrial membrane, remain one of the most enigmatic problems in modern bioenergetics. Recent high-resolution cryo-EM structures of complex I revealed… read more here.

Keywords: proton transfer; respiratory complex; proton; charged conduit ... See more keywords

Reverse Electron Transfer by Respiratory Complex I Catalyzed in a Modular Proteoliposome System

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recommendations! Published in 2022 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.2c00274

Abstract: Respiratory complex I is an essential metabolic enzyme that uses the energy from NADH oxidation and ubiquinone reduction to translocate protons across an energy transducing membrane and generate the proton motive force for ATP synthesis.… read more here.

Keywords: system; respiratory complex; proteoliposome system; electron transfer ... See more keywords

Kinetoplast DNA structure, RNA editing patterns and small respiratory Complex I in Trypanosoma musculi

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recommendations! Published in 2025 at "Communications Biology"

DOI: 10.1038/s42003-025-08883-2

Abstract: Kinetoplast (k) DNA, a specialized form of mitochondrial DNA in trypanosomes, is composed of catenated maxicircles and minicircles, and is essential for the survival of these parasitic protists. In this study, we provide a detailed… read more here.

Keywords: respiratory complex; trypanosoma; musculi; kinetoplast dna ... See more keywords

A leigh syndrome mutation perturbs long-range energy coupling in respiratory complex I

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recommendations! Published in 2025 at "Chemical Science"

DOI: 10.1039/d4sc04036h

Abstract: Respiratory complex I is a central enzyme of cellular energy metabolism that couples electron transfer with proton translocation across a biological membrane. In doing so, it powers oxidative phosphorylation that drives energy consuming processes. Mutations… read more here.

Keywords: respiratory complex; energy; electron transfer; mutation ... See more keywords

From the ‘black box' to ‘domino effect' mechanism: what have we learned from the structures of respiratory complex I

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recommendations! Published in 2023 at "Biochemical Journal"

DOI: 10.1042/bcj20210285

Abstract: My group and myself have studied respiratory complex I for almost 30 years, starting in 1994 when it was known as a L-shaped giant ‘black box' of bioenergetics. First breakthrough was the X-ray structure of… read more here.

Keywords: domino effect; respiratory complex; black box; mechanism ... See more keywords
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Structure of the human respiratory complex II

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recommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2216713120

Abstract: Significance Human complex II deficiency resulting from mutations in the structural subunit genes can lead to metabolic disease or cancer. Here, we have determined the structure of this complex which explains how it effectively transports… read more here.

Keywords: structure human; respiratory complex; structure; human respiratory ... See more keywords

Cryo-EM structure of Neurospora crassa respiratory complex IV

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recommendations! Published in 2019 at "IUCrJ"

DOI: 10.1107/s2052252519007486

Abstract: The cryo-EM structure of Neurospora crassa respiratory complex IV was determined to 5.5 Å resolution and is compared with related structures from Saccharomyces cerevisiae and Bos taurus. read more here.

Keywords: neurospora crassa; respiratory complex; structure neurospora; cryo structure ... See more keywords

Mitochondrial respiratory complex III sustains IL-10 production in activated macrophages and promotes tumor-mediated immune evasion

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recommendations! Published in 2025 at "Science Advances"

DOI: 10.1126/sciadv.adq7307

Abstract: The cytokine interleukin-10 (IL-10) limits the immune response and promotes resolution of acute inflammation. Because of its immunosuppressive effects, IL-10 up-regulation is a common feature of tumor progression and metastasis. Recently, IL-10 regulation has been… read more here.

Keywords: respiratory complex; mitochondrial respiratory; complex iii; activated macrophages ... See more keywords