Docking and molecular simulations reveal a quinone binding site on the surface of respiratory complex I.
Sign Up to like & getrecommendations! Published in 2022 at "FEBS letters"
DOI: 10.1002/1873-3468.14346
Abstract: The first component of the mitochondrial electron transport chain is respiratory complex I. Several high-resolution structures of complex I from different species have been resolved. However, despite these significant achievements, the mechanism of redox-coupled proton… read more here.
Keywords: surface; docking molecular; binding site; site ... See more keywords
The ins and outs of the flavin mononucleotide cofactor of respiratory complex I
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DOI: 10.1002/iub.2600
Abstract: The flavin mononucleotide (FMN) cofactor of respiratory complex I occupies a key position in the electron transport chain. Here, the electrons coming from NADH start the sequence of oxidoreduction reactions, which drives the generation of… read more here.
Keywords: respiratory complex; cofactor respiratory; cofactor; ins outs ... See more keywords
Activation of respiratory Complex I from Escherichia coli studied by fluorescent probes
Sign Up to like & getrecommendations! Published in 2017 at "Heliyon"
DOI: 10.1016/j.heliyon.2016.e00224
Abstract: Respiratory Complex I from E. coli may exist in two interconverting forms: resting (R) and active (A). The R/A transition of purified, solubilized Complex I occurring upon turnover was studied employing two different fluorescent probes,… read more here.
Keywords: activation respiratory; coli; respiratory complex; fluorescent probes ... See more keywords
Reverse Electron Transfer by Respiratory Complex I Catalyzed in a Modular Proteoliposome System
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c00274
Abstract: Respiratory complex I is an essential metabolic enzyme that uses the energy from NADH oxidation and ubiquinone reduction to translocate protons across an energy transducing membrane and generate the proton motive force for ATP synthesis.… read more here.
Keywords: system; respiratory complex; proteoliposome system; electron transfer ... See more keywords
From the ‘black box' to ‘domino effect' mechanism: what have we learned from the structures of respiratory complex I
Sign Up to like & getrecommendations! Published in 2023 at "Biochemical Journal"
DOI: 10.1042/bcj20210285
Abstract: My group and myself have studied respiratory complex I for almost 30 years, starting in 1994 when it was known as a L-shaped giant ‘black box' of bioenergetics. First breakthrough was the X-ray structure of… read more here.
Keywords: domino effect; respiratory complex; black box; mechanism ... See more keywords
Structure of the human respiratory complex II
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2216713120
Abstract: Significance Human complex II deficiency resulting from mutations in the structural subunit genes can lead to metabolic disease or cancer. Here, we have determined the structure of this complex which explains how it effectively transports… read more here.
Keywords: structure human; respiratory complex; structure; human respiratory ... See more keywords
Cryo-EM structure of Neurospora crassa respiratory complex IV
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DOI: 10.1107/s2052252519007486
Abstract: The cryo-EM structure of Neurospora crassa respiratory complex IV was determined to 5.5 Å resolution and is compared with related structures from Saccharomyces cerevisiae and Bos taurus. read more here.
Keywords: neurospora crassa; respiratory complex; structure neurospora; cryo structure ... See more keywords
Loss of respiratory complex I subunit NDUFB10 affects complex I assembly and supercomplex formation
Sign Up to like & getrecommendations! Published in 2023 at "Biological Chemistry"
DOI: 10.1515/hsz-2022-0309
Abstract: Abstract The orchestrated activity of the mitochondrial respiratory or electron transport chain (ETC) and ATP synthase convert reduction power (NADH, FADH2) into ATP, the cell’s energy currency in a process named oxidative phosphorylation (OXPHOS). Three… read more here.
Keywords: loss respiratory; respiratory complex; subunit; formation ... See more keywords
Mitochondrial DNA Changes in Respiratory Complex I Genes in Brain Gliomas
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11041183
Abstract: Mitochondria are organelles necessary for oxidative phosphorylation. The interest in the role of mitochondria in the process of carcinogenesis results from the fact that a respiratory deficit is found in dividing cells, especially in cells… read more here.
Keywords: respiratory complex; dna; genes brain; brain gliomas ... See more keywords
Cryo-EM structure of respiratory complex I at work
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.39213
Abstract: Mitochondrial complex I has a key role in cellular energy metabolism, generating a major portion of the proton motive force that drives aerobic ATP synthesis. The hydrophilic arm of the L-shaped ~1 MDa membrane protein… read more here.
Keywords: respiratory complex; structure respiratory; cryo structure; complex work ... See more keywords
Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.55845
Abstract: Disruption of mitochondrial function selectively targets tumour cells that are dependent on oxidative phosphorylation. However, due to their high energy demands, cardiac cells are disproportionately targeted by mitochondrial toxins resulting in a loss of cardiac… read more here.
Keywords: anti cancer; cancer; mitochondrial respiratory; respiratory complex ... See more keywords