Increased supra-organization is a dynamic multistep remodelling of respiratory complexes against proteostasis stress.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cell science"
DOI: 10.1242/jcs.248492
Abstract: Proteasome-mediated degradation of misfolded proteins prevents aggregation inside and outside mitochondria. But how do cells safeguard mitochondrial proteome and function despite increased aggregation during proteasome-inactivation? Here, using a novel two-dimensional complexome profiling strategy, we report… read more here.
Keywords: increased supra; respiratory complexes; stress; supra organization ... See more keywords
Uncovering interactions between mycobacterial respiratory complexes to target drug-resistant Mycobacterium tuberculosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.980844
Abstract: Mycobacterium tuberculosis remains a leading cause of infectious disease morbidity and mortality for which new drug combination therapies are needed. Mycobacterial bioenergetics has emerged as a promising space for the development of novel therapeutics. Further… read more here.
Keywords: mycobacterium tuberculosis; respiratory complexes; respiratory; mycobacterial respiratory ... See more keywords
A Structural Perspective on the RNA Editing of Plant Respiratory Complexes
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DOI: 10.3390/ijms23020684
Abstract: The last steps of respiration, a core energy-harvesting process, are carried out by a chain of multi-subunit complexes in the inner mitochondrial membrane. Several essential subunits of the respiratory complexes are RNA-edited in plants, frequently… read more here.
Keywords: rna editing; respiratory complexes; structural perspective; respiratory ... See more keywords
Mitochondrial DNA Changes in Genes of Respiratory Complexes III, IV and V Could Be Related to Brain Tumours in Humans
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DOI: 10.3390/ijms232012131
Abstract: Mitochondrial DNA changes can contribute to both an increased and decreased likelihood of cancer. This process is complex and not fully understood. Polymorphisms and mutations, especially those of the missense type, can affect mitochondrial functions,… read more here.
Keywords: respiratory complexes; dna; dna changes; brain ... See more keywords