Toxicities of opioid analgesics: respiratory depression, histamine release, hemodynamic changes, hypersensitivity, serotonin toxicity.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of toxicology"
DOI: 10.1007/s00204-021-03068-2
Abstract: Opioid-induced respiratory depression is potentially life-threatening and often regarded as the main hazard of opioid use. Main cause of death is cardiorespiratory arrest with hypoxia and hypercapnia. Respiratory depression is mediated by opioid μ receptors… read more here.
Keywords: histamine; toxicity; hemodynamic changes; respiratory depression ... See more keywords
Opioid-induced respiratory depression in humans: a review of pharmacokinetic-pharmacodynamic modelling of reversal.
Sign Up to like & getrecommendations! Published in 2019 at "British journal of anaesthesia"
DOI: 10.1016/j.bja.2018.12.023
Abstract: BACKGROUND Opioids are potent painkillers but come with serious adverse effects ranging from addiction to potentially lethal respiratory depression. A variety of drugs with separate mechanisms of action are available to prevent or reverse opioid-induced… read more here.
Keywords: induced respiratory; reversal; opioid induced; respiratory depression ... See more keywords
Quantifying the incidence of clinically significant respiratory depression in women with and without obesity class III receiving neuraxial morphine for post-cesarean analgesia: a retrospective cohort study.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of obstetric anesthesia"
DOI: 10.1016/j.ijoa.2021.103187
Abstract: BACKGROUND Obesity is a suspected risk factor for respiratory depression following neuraxial morphine for post-cesarean analgesia, however monitoring guidelines for obese obstetric patients are based on small, limited studies. We tested the hypothesis that clinically… read more here.
Keywords: clinically significant; neuraxial morphine; significant respiratory; respiratory depression ... See more keywords
Respiratory depression in low acuity hospital settings–Seeking answers from the PRODIGY trial
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Critical Care"
DOI: 10.1016/j.jcrc.2018.06.014
Abstract: &NA; Predicting episodes or severity of cardiorespiratory decompensation has proved to be challenging in patients with stable surgical or medical conditions, recovering on the general care floor (ward). Critical cardiorespiratory events on hospital floors may… read more here.
Keywords: acuity hospital; depression; prodigy trial; respiratory depression ... See more keywords
Inhibition of protein kinase A and GIRK channel reverses fentanyl-induced respiratory depression
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.04.029
Abstract: Opioid-induced respiratory depression is a major obstacle to improving the clinical management of moderate to severe chronic pain. Opioids inhibit neuronal activity via various pathways, including calcium channels, adenylyl cyclase, and potassium channels. Currently, the… read more here.
Keywords: depression; induced respiratory; fentanyl induced; respiratory depression ... See more keywords
Developing an animal model to detect drug–drug interactions impacting drug-induced respiratory depression⋆
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology Reports"
DOI: 10.1016/j.toxrep.2020.01.008
Abstract: Highlights • A model to assess drug interaction effects on drug induced respiratory depression.• Plasma oxycodone level AUC was 113 % higher when the two drugs were co-administered.• Diazepam showed synergistic effects on respiratory depression… read more here.
Keywords: induced respiratory; drug induced; drug; model ... See more keywords
Searching for Synthetic Opioid Rescue Agents: Identification of a Potent Opioid Agonist with Reduced Respiratory Depression.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c00333
Abstract: While in the process of designing more effective synthetic opioid rescue agents, we serendipitously identified a new chemotype of potent synthetic opioid. Here, we report that conformational constraint of a piperazine ring converts a mu… read more here.
Keywords: opioid rescue; rescue agents; synthetic opioid; respiratory depression ... See more keywords
Tandospirone prevents anesthetic-induced respiratory depression through 5-HT1A receptor activation in rats
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-024-84440-x
Abstract: Respiratory depression is a side effect of anesthetics. Treatment with specific antagonists or respiratory stimulants can reverse respiratory depression caused by anesthetics; however, they also interfere with the sedative effects of anesthetics. Previous studies have… read more here.
Keywords: ht1a receptor; depression; tandospirone; respiratory depression ... See more keywords
μ-Opioid Receptor Agonists: Do They Have Utility in the Treatment of Acute Pain?
Sign Up to like & getrecommendations! Published in 2018 at "Anesthesiology"
DOI: 10.1097/aln.0000000000002177
Abstract: Anesthesiology, V 128 • No 5 867 May 2018 I this issue of A NESTHESIOLOGY, Roozekrans et al.1 have revisited the utility function to emphasize the balance between therapeutic efficacy and toxicity of opioids. They… read more here.
Keywords: opioid receptor; utility function; utility; receptor agonists ... See more keywords
Review of Postoperative Respiratory Depression: From Recovery Room to General Care Unit.
Sign Up to like & getrecommendations! Published in 2022 at "Anesthesiology"
DOI: 10.1097/aln.0000000000004391
Abstract: Contemporary evidence suggests that episodes of respiratory depression during anesthesia recovery are associated with subsequent respiratory complications in general care units. read more here.
Keywords: general care; respiratory depression; recovery;
Morphine and Hydromorphone Effects, Side Effects and Variability - a Crossover Study in Human Volunteers.
Sign Up to like & getrecommendations! Published in 2023 at "Anesthesiology"
DOI: 10.1097/aln.0000000000004567
Abstract: Background: Balancing between opioid analgesia and respiratory depression continues to challenge clinicians in perioperative, emergency department, and other acute care settings. Morphine and hydromorphone are postoperative analgesic standards. Nevertheless, their comparative effects and side effects,… read more here.
Keywords: respiratory depression; hydromorphone; morphine hydromorphone; respiratory ... See more keywords