Muc5b is mainly expressed and sialylated in the nasal olfactory epithelium whereas Muc5ac is exclusively expressed and fucosylated in the nasal respiratory epithelium
Sign Up to like & getrecommendations! Published in 2019 at "Histochemistry and Cell Biology"
DOI: 10.1007/s00418-019-01785-5
Abstract: The nose is a complex organ that filters and warms breathing airflow. The nasal epithelium is the first barrier between the host and the external environment and is covered by a mucus gel that is… read more here.
Keywords: whereas muc5ac; respiratory epithelium; epithelium; muc5b mainly ... See more keywords
Primary ciliogenesis is a crucial step for multiciliated cell determinism in the respiratory epithelium
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16729
Abstract: The alteration of the mucociliary clearance is a major hallmark of respiratory diseases related to structural and functional cilia abnormalities such as chronic obstructive pulmonary diseases (COPD), asthma and cystic fibrosis. Primary cilia and motile… read more here.
Keywords: primary ciliogenesis; cell; respiratory epithelium; primary cilia ... See more keywords
Rhinovirus increases Moraxella catarrhalis adhesion to the respiratory epithelium
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DOI: 10.3389/fcimb.2022.1060748
Abstract: Rhinovirus causes many types of respiratory illnesses, ranging from minor colds to exacerbations of asthma. Moraxella catarrhalis is an opportunistic pathogen that is increased in abundance during rhinovirus illnesses and asthma exacerbations and is associated… read more here.
Keywords: infection; rhinovirus; moraxella catarrhalis; respiratory epithelium ... See more keywords
Co-infection of the respiratory epithelium, scene of complex functional interactions between viral, bacterial, and human neuraminidases
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DOI: 10.3389/fmicb.2023.1137336
Abstract: The activity of sialic acids, known to play critical roles in biology and many pathological processes, is finely regulated by a class of enzymes called sialidases, also known as neuraminidases. These are present in mammals… read more here.
Keywords: epithelium scene; viral bacterial; complex functional; respiratory epithelium ... See more keywords
Mucociliary Respiratory Epithelium Integrity in Molecular Defense and Susceptibility to Pulmonary Viral Infections
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DOI: 10.3390/biology10020095
Abstract: Simple Summary Mucociliary clearance constitutes an innate lung defense mechanism that is primarily driven by ciliated cells. Respiratory mucus traps pathogens entering the airways, and lung cilia propel them outward via their coordinated directional motion.… read more here.
Keywords: respiratory; mucociliary clearance; respiratory epithelium; defense ... See more keywords
SARS-CoV-2 Infection Dysregulates Cilia and Basal Cell Homeostasis in the Respiratory Epithelium of Hamsters
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23095124
Abstract: Similar to many other respiratory viruses, SARS-CoV-2 targets the ciliated cells of the respiratory epithelium and compromises mucociliary clearance, thereby facilitating spread to the lungs and paving the way for secondary infections. A detailed understanding… read more here.
Keywords: cov infection; infection; respiratory epithelium; sars cov ... See more keywords