Computer-Aided Discovery and Redesign for Respiratory Sensitization: A Tiered Mechanistic Model to Deliver Robust Performance Across a Diverse Chemical Space.
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DOI: 10.1021/acs.chemrestox.2c00224
Abstract: Asthma is among the most common occupational diseases with considerable public health and economic costs. Chemicals that induce hypersensitivity in the airways can cause respiratory distress and comorbidities with respiratory infections such as COVID. Robust… read more here.
Keywords: redesign; aided discovery; respiratory sensitization; model ... See more keywords
Evaluation of animal toxicity studies with diisocyanates regarding presence of thresholds for induction and elicitation of respiratory allergy by quantitative weight of evidence
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology and Industrial Health"
DOI: 10.1177/07482337211069234
Abstract: Animal toxicity studies on diisocyanates were evaluated using quantitative weight of evidence (QWoE) to test the hypothesis that the dose-response curve shows a threshold for the induction and/or elicitation of respiratory sensitization. A literature search… read more here.
Keywords: elicitation respiratory; respiratory; respiratory sensitization; induction ... See more keywords