Imputation strategies when a continuous outcome is to be dichotomized for responder analysis: a simulation study
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DOI: 10.1186/s12874-019-0793-x
Abstract: In many clinical trials continuous outcomes are dichotomized to compare proportions of patients who respond. A common and recommended approach to handling missing data in responder analysis is to impute as non-responders, despite known biases.… read more here.
Keywords: imputation; response; multiple imputation; responder analysis ... See more keywords