A response-adaptive design of initial therapy for emergency department patients with heart failure.
Sign Up to like & getrecommendations! Published in 2017 at "Contemporary clinical trials"
DOI: 10.1016/j.cct.2016.11.002
Abstract: Finding safe and effective treatments for acute heart failure syndrome (AHFS) is a high priority. More than 80% of patients with AHFS who present to emergency departments are treated identically with intravenous diuretics, despite recognition… read more here.
Keywords: heart; heart failure; emergency; response adaptive ... See more keywords
Multi-arm response-adaptive designs for circular responses
Sign Up to like & getrecommendations! Published in 2019 at "Journal of The Korean Statistical Society"
DOI: 10.1016/j.jkss.2019.03.005
Abstract: Abstract A multi-arm response-adaptive allocation design is developed for circular treatment outcomes. Several exact and asymptotic properties of the design are studied. Stage-wise treatment selection procedures based on the proposed response-adaptive design are also suggested… read more here.
Keywords: response; designs circular; response adaptive; arm response ... See more keywords
Statistical inference for response adaptive randomization procedures with adjusted optimal allocation proportions
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2016.1269780
Abstract: ABSTRACT Seamless phase II/III clinical trials have attracted increasing attention recently. They mainly use Bayesian response adaptive randomization (RAR) designs. There has been little research into seamless clinical trials using frequentist RAR designs because of… read more here.
Keywords: response adaptive; allocation proportions; statistical inference; adaptive randomization ... See more keywords
Urn models for response-adaptive randomized designs: a simulation study based on a non-adaptive randomized trial
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2018.1452024
Abstract: ABSTRACT Recently, response-adaptive designs have been proposed in randomized clinical trials to achieve ethical and/or cost advantages by using sequential accrual information collected during the trial to dynamically update the probabilities of treatment assignments. In… read more here.
Keywords: trial; non adaptive; adaptive randomized; treatment ... See more keywords
Sequential Monte Carlo for response adaptive randomized trials.
Sign Up to like & getrecommendations! Published in 2018 at "Biostatistics"
DOI: 10.1093/biostatistics/kxy048
Abstract: Response adaptive randomized clinical trials have gained popularity due to their flexibility for adjusting design components, including arm allocation probabilities, at any point in the trial according to the intermediate results. In the Bayesian framework,… read more here.
Keywords: adaptive randomized; monte carlo; response adaptive; sequential monte ... See more keywords
Bayesian response-adaptive designs for basket trials.
Sign Up to like & getrecommendations! Published in 2017 at "Biometrics"
DOI: 10.1111/biom.12668
Abstract: We develop a general class of response-adaptive Bayesian designs using hierarchical models, and provide open source software to implement them. Our work is motivated by recent master protocols in oncology, where several treatments are investigated… read more here.
Keywords: designs basket; bayesian response; adaptive designs; response adaptive ... See more keywords
Inference in response-adaptive clinical trials when the enrolled population varies over time.
Sign Up to like & getrecommendations! Published in 2021 at "Biometrics"
DOI: 10.1111/biom.13582
Abstract: A common assumption of data analysis in clinical trials is that the patient population, as well as treatment effects, do not vary during the course of the study. However, when trials enroll patients over several… read more here.
Keywords: time; adaptive clinical; clinical trials; response adaptive ... See more keywords
An alternative metric for evaluating the potential patient benefit of response-adaptive randomization procedures.
Sign Up to like & getrecommendations! Published in 2022 at "Biometrics"
DOI: 10.1111/biom.13673
Abstract: When planning a two-arm group sequential clinical trial with a binary primary outcome that has severe implications for quality of life (e.g., mortality), investigators may strive to find the design that maximizes in-trial patient benefit.… read more here.
Keywords: adaptive randomization; response adaptive; patient benefit; trial ... See more keywords
A multi-treatment response adaptive design for ordinal categorical responses
Sign Up to like & getrecommendations! Published in 2019 at "Statistical Methods in Medical Research"
DOI: 10.1177/0962280219846152
Abstract: A multi-treatment response adaptive procedure is developed considering “comparison with the best” philosophy of multiple comparison procedures for clinical trials with ordinal categorical responses, when there is no shared control. For each response category, we… read more here.
Keywords: treatment response; response; ordinal categorical; response adaptive ... See more keywords
Response-adaptive treatment randomization for multiple comparisons of treatments with recurrent event responses
Sign Up to like & getrecommendations! Published in 2022 at "Statistical Methods in Medical Research"
DOI: 10.1177/09622802221095244
Abstract: Recurrent event responses are frequently encountered during clinical trials of treatments for certain diseases, such as asthma. The recurrence rates of different treatments are often compared by applying the negative binomial model. In addition, a… read more here.
Keywords: treatment; response adaptive; adaptive treatment; treatment allocation ... See more keywords
Familywise error rate control for block response-adaptive randomization.
Sign Up to like & getrecommendations! Published in 2022 at "Statistical methods in medical research"
DOI: 10.1177/09622802231167437
Abstract: Response-adaptive randomization allows the probabilities of allocating patients to treatments in a clinical trial to change based on the previously observed response data, in order to achieve different experimental goals. One concern over the use… read more here.
Keywords: adaptive randomization; response adaptive; error rate; response ... See more keywords