The Pandemic Response Box—Accelerating Drug Discovery Efforts after Disease Outbreaks
Sign Up to like & getrecommendations! Published in 2022 at "ACS Infectious Diseases"
DOI: 10.1021/acsinfecdis.1c00527
Abstract: The current Covid-19 pandemic has underlined the need for a more coordinated and forward-looking investment in the search for new medicines targeting emerging health care threats. Repositioning currently approved drugs is a popular approach to… read more here.
Keywords: drug discovery; pandemic response; disease; response box ... See more keywords
Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-020-20629-8
Abstract: Chemical matter is needed to target the divergent biology associated with the different life cycle stages of Plasmodium . Here, we report the parallel de novo screening of the Medicines for Malaria Venture (MMV)Â Pandemic Response… read more here.
Keywords: pandemic response; response box; transmission blocking;
Screening of Pandemic Response Box Library Reveals the High Activity of Olorofim against Pathogenic Sporothrix Species
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Fungi"
DOI: 10.3390/jof8101004
Abstract: The increase in the prevalence and severity of fungal infections and the resistance to available antifungals highlights the imperative need for novel therapeutics and the search for new targets. High-content screening of libraries containing hundreds… read more here.
Keywords: pandemic response; response box; box library; activity ... See more keywords