LAUSR

The Pandemic Response Box—Accelerating Drug Discovery Efforts after Disease Outbreaks

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1 Published in 2022 at "ACS Infectious Diseases"

DOI: 10.1021/acsinfecdis.1c00527

Abstract: The current Covid-19 pandemic has underlined the need for a more coordinated and forward-looking investment in the search for new medicines targeting emerging health care threats. Repositioning currently approved drugs is a popular approach to… read more here.

Keywords: drug discovery; pandemic response; disease; response box ... See more keywords

Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box

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1 Published in 2021 at "Nature Communications"

DOI: 10.1038/s41467-020-20629-8

Abstract: Chemical matter is needed to target the divergent biology associated with the different life cycle stages of Plasmodium . Here, we report the parallel de novo screening of the Medicines for Malaria Venture (MMV) Pandemic Response… read more here.

Keywords: pandemic response; response box; transmission blocking;

Investigating the Antimicrobial Potential of 560 Compounds from the Pandemic Response Box and COVID Box against Resistant Gram-Negative Bacteria

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0 Published in 2024 at "Antibiotics"

DOI: 10.3390/antibiotics13080723

Abstract: Antimicrobial resistance (AMR) has emerged as a significant threat to public health, particularly in infections caused by critically important Gram-negative bacteria. The development of novel antibiotics has its limitations, and therefore it is crucial to… read more here.

Keywords: gram negative; response box; pandemic response; 560 compounds ... See more keywords

Screening of Pandemic Response Box Library Reveals the High Activity of Olorofim against Pathogenic Sporothrix Species

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1 Published in 2022 at "Journal of Fungi"

DOI: 10.3390/jof8101004

Abstract: The increase in the prevalence and severity of fungal infections and the resistance to available antifungals highlights the imperative need for novel therapeutics and the search for new targets. High-content screening of libraries containing hundreds… read more here.

Keywords: pandemic response; response box; box library; activity ... See more keywords

Novel Anti-Enterovirus A71 Compounds Discovered by Repositioning Antivirals from the Open-Source MMV Pandemic Response Box

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0 Published in 2024 at "Pharmaceuticals"

DOI: 10.3390/ph17060785

Abstract: The open-source drug library, namely, MMV Pandemic Response Box, contains 153 antiviral agents, a chemically and pharmacologically diverse mixture of early-stage, emerging anti-infective scaffolds, and mature compounds currently undergoing clinical development. Hence, the Pandemic Response… read more here.

Keywords: open source; pandemic response; response box; a71 ... See more keywords