DNA2 protein destruction dictates DNA hyperexcision, cGAS–STING activation, and innate immune response in CDK12-deregulated cancers
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2413732122
Abstract: Significance The protein kinase gene CDK12 is frequently altered genetically in human cancers including prostate, ovarian, and breast cancer. Loss of CDK12 has been linked to enhanced anticancer immunity in prostate cancer. Here, we report… read more here.
Keywords: dna2 protein; cdk12; immune response; response cdk12 ... See more keywords