T19. GLUTAMATE AND RESPONSE TO CLOZAPINE IN TREATMENT RESISTANT SCHIZOPHRENIA
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DOI: 10.1093/schbul/sbaa029.579
Abstract: Abstract Background The mechanisms that underlie and may mediate the therapeutic response to clozapine in treatment resistant schizophrenia (TRS) are unclear. Basic science studies have indicated that clozapine may modulate brain glutamate, but this has… read more here.
Keywords: response clozapine; schizophrenia; glutamate; clozapine treatment ... See more keywords
M212. A SYSTEMATIC REVIEW AND META-ANALYSIS OF CLINICAL VARIABLES ASSOCIATED WITH RESPONSE TO CLOZAPINE IN TREATMENT RESISTANT SCHIZOPHRENIA
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DOI: 10.1093/schbul/sbaa030.524
Abstract: Abstract Background Approximately one third of patients with schizophrenia display suboptimal response to two trials of non-clozapine antipsychotic medication and may be termed treatment resistant. Clozapine is the only licensed pharmacotherapy for treatment resistant schizophrenia,… read more here.
Keywords: response; clozapine; analysis; response clozapine ... See more keywords
Dopamine supersensitivity psychosis and delay of clozapine treatment in patients with treatment-resistant schizophrenia
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DOI: 10.1097/yic.0000000000000442
Abstract: Both the underutilization of clozapine and treatment resistance of patients to clozapine are serious problems worldwide. Identifying clinical markers predicting response to clozapine would help clinicians more effectively utilize clozapine treatment. The present study retrospectively… read more here.
Keywords: response clozapine; clozapine treatment; age; delay clozapine ... See more keywords
Genetic determinants associated with response to clozapine in schizophrenia: an umbrella review
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DOI: 10.1097/ypg.0000000000000320
Abstract: Objective Clozapine response varies widely from person to person, which may be due to inter-individual genetic variability. This umbrella review aims to summarize the current evidence on associations between pharmacodynamic genes and response to clozapine… read more here.
Keywords: clozapine response; genetic determinants; response clozapine; clozapine ... See more keywords