Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose–response data: Margin of exposure case study of 48 compounds with both in vivo mutagenicity and carcinogenicity dose–response data
Sign Up to like & getrecommendations! Published in 2022 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22517
Abstract: Quantitative relationships between carcinogenic potency and mutagenic potency have been previously examined using a benchmark dose (BMD)‐based approach. We extended those analyses by using human exposure data for 48 compounds to calculate carcinogenicity‐derived and genotoxicity‐derived… read more here.
Keywords: carcinogenicity; response data; dose response; genotoxicity ... See more keywords
Quantitative interpretation of ToxTracker dose–response data for potency comparisons and mode‐of‐action determination
Sign Up to like & getrecommendations! Published in 2023 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22525
Abstract: ToxTracker is an in vitro mammalian stem cell‐based reporter assay that detects activation of specific cellular signaling pathways (DNA damage, oxidative stress, and/or protein damage) upon chemical exposure using flow cytometry. Here we used quantitative… read more here.
Keywords: stress; potency; response data; dose response ... See more keywords
Incorporating covariate information in the covariance structure of misaligned spatial data
Sign Up to like & getrecommendations! Published in 2020 at "Environmetrics"
DOI: 10.1002/env.2623
Abstract: Incorporating covariates in the second‐ structure of spatial processes is an effective way of building flexible nonstationary covariance models. Fitting these covariances requires covariates to already exist at locations where there is response data. However,… read more here.
Keywords: covariance structure; response data; structure; covariate ... See more keywords
Estimation of seismic wave incident angle using vibration response data and stacking ensemble algorithm
Sign Up to like & getrecommendations! Published in 2021 at "Computers and Geotechnics"
DOI: 10.1016/j.compgeo.2021.104255
Abstract: Abstract The determination of the incident angle of an earthquake is one of the critical research issues in modeling the seismic input mechanism at a dam site and it is also for geological exploration. At… read more here.
Keywords: angle; incident angle; stacking ensemble; estimation ... See more keywords
Use of Physiologically Based Kinetic Modeling-Facilitated Reverse Dosimetry to Predict In Vivo Acute Toxicity of Tetrodotoxin in Rodents
Sign Up to like & getrecommendations! Published in 2022 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfac022
Abstract: Abstract In this study, the ability of a new in vitro/in silico quantitative in vitro–in vivo extrapolation (QIVIVE) methodology was assessed to predict the in vivo neurotoxicity of tetrodotoxin (TTX) in rodents. In vitro concentration–response… read more here.
Keywords: based kinetic; response data; vivo; methodology ... See more keywords
Frequency Response Data-Driven LPV Controller Synthesis for MIMO Systems
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Control Systems Letters"
DOI: 10.1109/lcsys.2021.3139734
Abstract: The linear parameter-varying framework enables systematic control design approaches to meet increasing performance requirements and complexity of systems. The aim of this letter is to develop local frequency response data-based analysis and synthesis conditions for… read more here.
Keywords: response data; synthesis; controller; data driven ... See more keywords
A Feasibility Study of Autism Behavioral Markers in Spontaneous Facial, Visual, and Hand Movement Response Data
Sign Up to like & getrecommendations! Published in 2018 at "IEEE Transactions on Neural Systems and Rehabilitation Engineering"
DOI: 10.1109/tnsre.2017.2768482
Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental disability with atypical traits in behavioral and physiological responses. These atypical traits in individuals with ASD may be too subtle and subjective to measure visually using tedious methods… read more here.
Keywords: spontaneous facial; hand movement; behavioral markers; hand ... See more keywords
ROADMAPS: An Online Database of Response Data, Dosing Regimens, and Toxicities of Approved Oncology Drugs as Single Agents to Guide Preclinical In Vivo Studies
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Research"
DOI: 10.1158/0008-5472.can-21-4151
Abstract: ROADMAPS includes data that can be used to identify tolerable dosing regimens with activity against a variety of human tumors in different mouse strains, providing a resource for planning preclinical studies. read more here.
Keywords: oncology; response data; online database; dosing regimens ... See more keywords
Abstract 2991: Integrative analysis of molecular and drug response data from clinical samples and PDTXs to identify pharmacogenomic associations in breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-2991
Abstract: Breast cancer is the most common cancer among women showing high clinical and molecular heterogeneity. Current clinical management causes patients overtreatment with implications on both patients’ quality of life and healthcare costs. Moreover, intrinsic or… read more here.
Keywords: response; breast cancer; drug; cancer ... See more keywords
A Universal Delayed Difference Model Fitting Dose-response Curves
Sign Up to like & getrecommendations! Published in 2021 at "Dose-Response"
DOI: 10.1177/15593258211062785
Abstract: Purpose Dose-response curves, which fit a multitude of experimental data derived from toxicology, are widely used in physics, chemistry, biology, and other fields. Although there are many dose-response models for fitting dose-response curves, the application… read more here.
Keywords: response; response curves; response data; dose response ... See more keywords
eeFit: a Microsoft Excel-embedded program for interactive analysis and fitting of experimental dose-response data.
Sign Up to like & getrecommendations! Published in 2019 at "BioTechniques"
DOI: 10.2144/btn-2018-0136
Abstract: We present here a software program dedicated to the fitting of experimental dose-response data, which integrates seamlessly with Excel and allows curve fitting plots and results to reside alongside data within Excel spreadsheets. The program,… read more here.
Keywords: dose response; excel; fitting experimental; program ... See more keywords