Distribution and characteristics of transactive response DNA binding protein 43 kDa pathology in progressive supranuclear palsy
Sign Up to like & getrecommendations! Published in 2017 at "Movement Disorders"
DOI: 10.1002/mds.26809
Abstract: This study aimed to determine the frequency of transactive response DNA binding protein 43 kDa pathology in PSP, the clinical features of patients with this pathology, and genetic risk factors for it. read more here.
Keywords: pathology; transactive response; binding protein; dna binding ... See more keywords
TonEBP Regulates PCNA Polyubiquitination in Response to DNA Damage through Interaction with SHPRH and USP1
Sign Up to like & getrecommendations! Published in 2019 at "iScience"
DOI: 10.1016/j.isci.2019.07.021
Abstract: Summary Polyubiquitination of proliferating cell nuclear antigen (PCNA) regulates the error-free template-switching mechanism for the bypass of DNA lesions during DNA replication. PCNA polyubiquitination is critical for the maintenance of genomic integrity; however, the underlying… read more here.
Keywords: response dna; dna damage; polyubiquitination; pcna polyubiquitination ... See more keywords
The Paf1 complex is required for RNA polymerase II removal in response to DNA damage
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2207332119
Abstract: Significance The highly conserved polymerase-associated factor 1 complex (PAF1C) is composed of five core subunits (Ctr9, Paf1, Cdc73, Rtf1, and Leo1) and involved in all stages of RNA polymerase II (RNAPII)-mediated transcription. This study involves… read more here.
Keywords: rna polymerase; dna damage; polymerase; response dna ... See more keywords
Oscillatory Dynamics of p53-Mdm2 Circuit in Response to DNA Damage Caused by Ionizing Radiation
Sign Up to like & getrecommendations! Published in 2020 at "IEEE/ACM Transactions on Computational Biology and Bioinformatics"
DOI: 10.1109/tcbb.2019.2899574
Abstract: Although the dynamical behavior of the p53-Mdm2 loop has been extensively studied, the understanding of the mechanism underlying the regulation of this pathway still remains limited. Herein, we developed an integrated model with five basic… read more here.
Keywords: ionizing radiation; p53 mdm2; level; p53 ... See more keywords
Frontotemporal dementia with trans‐activation response DNA‐binding protein 43 presenting with catatonic syndrome
Sign Up to like & getrecommendations! Published in 2018 at "Neuropathology"
DOI: 10.1111/neup.12442
Abstract: Catatonia is a clinical syndrome characterized by symptoms such as immobility, mutism, stupor, stereotypy, echophenomena, catalepsy, automatic obedience, posturing, negativism, gegenhalten and ambitendency. This syndrome occurs mostly in mood disorder and schizophrenic patients, and is… read more here.
Keywords: frontotemporal dementia; trans activation; binding protein; dna binding ... See more keywords
A J Domain Protein Functions as a Histone Chaperone to Maintain Genome Integrity and the Response to DNA Damage in a Human Fungal Pathogen
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DOI: 10.1128/mbio.03273-21
Abstract: DNA replication, gene expression, and genomic repair all require precise coordination of the many proteins that interact with DNA. This includes the histones as well as their chaperones. ABSTRACT Histone chaperoning ensures genomic integrity during… read more here.
Keywords: dna; damage; response dna; histone chaperone ... See more keywords
Chromosome Dynamics in Response to DNA Damage.
Sign Up to like & getrecommendations! Published in 2018 at "Annual review of genetics"
DOI: 10.1146/annurev-genet-120417-031334
Abstract: Recent advances in both the technologies used to measure chromatin movement and the biophysical analysis used to model them have yielded a fuller understanding of chromatin dynamics and the polymer structure that underlies it. Changes… read more here.
Keywords: dna damage; response; dna; dynamics response ... See more keywords
DNA damage response
Sign Up to like & getrecommendations! Published in 2018 at "Neurology"
DOI: 10.1212/wnl.0000000000004989
Abstract: An estimated 105 DNA lesions occur daily in the mammalian genome as a consequence of spontaneous decay, replication errors, and cell metabolism, including reactive oxygen species produced by the mitochondria. Oxidative stress is a major… read more here.
Keywords: response dna; dna damage; repair; dna ... See more keywords
USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1008178
Abstract: Mediator of IRF3 activation (MITA, also known as stimulator of interferon genes, STING) senses the second messenger cyclic GMP-AMP (cGAMP) which is synthesized upon DNA virus infection and activates innate antiviral immune response. It has… read more here.
Keywords: dna; immune response; response dna; mita ... See more keywords
The Cellular Response to DNA Damage: From DNA Repair to Polyploidy and Beyond
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076852
Abstract: A major challenge in treating patients with solid tumors is posed by intratumor heterogeneity, with different sub-populations of cancer cells within the same tumor exhibiting therapy resistance through different biological processes [...]. read more here.
Keywords: dna repair; dna; response dna; cellular response ... See more keywords