Rapid antidepressant‐like effect of Fructus Aurantii depends on cAMP‐response element binding protein/Brain‐derived neurotrophic facto by mediating synaptic transmission
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DOI: 10.1002/ptr.6812
Abstract: Several studies reported the relative antidepressant effects of Fructus Aurantii (FRA) with repeated treatment, the rapid antidepressant effects of FRA and the underlying mechanisms remained unclear. We, therefore, examined the rapid antidepressant actions of FRA… read more here.
Keywords: camp response; fructus aurantii; element binding; rapid antidepressant ... See more keywords
Dissection of c-AMP Response Element Architecture by Using Genomic and Episomal Massively Parallel Reporter Assays.
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DOI: 10.1016/j.cels.2020.05.011
Abstract: In eukaryotes, transcription factors (TFs) orchestrate gene expression by binding to TF-binding sites (TFBSs) and localizing transcriptional co-regulators and RNA polymerase II to cis-regulatory elements. However, we lack a basic understanding of the relationship between… read more here.
Keywords: massively parallel; amp response; expression; parallel reporter ... See more keywords
PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding protein
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DOI: 10.1093/neuonc/noy068
Abstract: Background Hyperactivation of phosphoinositide 3-kinase (PI3K) signaling is common in cancers, but the precise role of the pathway in glioma biology remains to be determined. Some understanding of PI3K signaling mechanisms in brain cancer comes… read more here.
Keywords: camp response; pi3k; binding protein; element binding ... See more keywords
cAMP Response Element-Binding Protein- and Phosphorylation-Dependent Regulation of Tyrosine Hydroxylase by PAK4: Implications for Dopamine Replacement Therapy
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DOI: 10.14348/molcells.2021.2250
Abstract: Parkinson’s disease (PD) is characterized by a progressive loss of dopamine-producing neurons in the midbrain, which results in decreased dopamine levels accompanied by movement symptoms. Oral administration of l-3,4-dihydroxyphenylalanine (L-dopa), the precursor of dopamine, provides… read more here.
Keywords: camp response; binding protein; element binding; tyrosine hydroxylase ... See more keywords
β-Catenin Regulates the Expression of cAMP Response Element-Binding Protein 1 in Squamous Cell Carcinoma Cells
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DOI: 10.5021/ad.2018.30.1.119
Abstract: Vol. 30, No. 1, 2018 119 Received October 21, 2016, Revised January 31, 2017, Accepted for publication February 8, 2017 Corresponding author: Chang-Deok Kim, Department of Dermatology, Chungnam National University School of Medicine, 266 Munhwa-ro,… read more here.
Keywords: camp response; regulates expression; catenin regulates; dermatology ... See more keywords