Transcriptional activation of S100A2 expression by HIF‐1α via binding to the hypomethylated hypoxia response elements in HCC cells
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23393
Abstract: Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal cancers. Dysregulation of S100A2 has recently been found in many cancers including HCC. However, its regulatory mechanism in HCC remains poorly understood, especially in… read more here.
Keywords: s100a2; hypoxia response; response elements; hcc ... See more keywords
Antioxidant response elements: Discovery, classes, regulation and potential applications
Sign Up to like & getrecommendations! Published in 2018 at "Redox Biology"
DOI: 10.1016/j.redox.2018.05.002
Abstract: Exposure to antioxidants and xenobiotics triggers the expression of a myriad of genes encoding antioxidant proteins, detoxifying enzymes, and xenobiotic transporters to offer protection against oxidative stress. This articulated universal mechanism is regulated through the… read more here.
Keywords: antioxidant response; oxidative stress; elements discovery; regulation ... See more keywords
Single molecule studies reveal that p53 tetramers dynamically bind response elements containing one or two half sites
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-73234-6
Abstract: The tumor suppressor protein p53 is critical for cell fate decisions, including apoptosis, senescence, and cell cycle arrest. p53 is a tetrameric transcription factor that binds DNA response elements to regulate transcription of target genes.… read more here.
Keywords: dna; p53 tetramers; half sites; p53 ... See more keywords
Functional Definition of Thyroid Hormone Response Elements Based on a Synthetic STARR-seq Screen
Sign Up to like & getrecommendations! Published in 2022 at "Endocrinology"
DOI: 10.1101/2022.02.23.481571
Abstract: When bound to thyroid hormone, the nuclear receptor TRα1 activates the transcription of a number of genes in many cell types. It mainly acts by binding DNA as an heterodimer with RXRs at specific response… read more here.
Keywords: response elements; thyroid hormone; starr seq; hormone response ... See more keywords
ZFARED: A Database of the Antioxidant Response Elements in Zebrafish
Sign Up to like & getrecommendations! Published in 2019 at "Current Bioinformatics"
DOI: 10.2174/1574893614666191018172213
Abstract: Antioxidant Response Elements (ARE) play a key role in the expression of Nrf2 target genes by regulating the Keap1-Nrf2-ARE pathway, which offers protection against toxic agents and oxidative stress-induced diseases. To develop a database of… read more here.
Keywords: antioxidant response; developed using; database developed; database ... See more keywords
Expanding the repertoire of glucocorticoid receptor target genes by engineering genomic response elements
Sign Up to like & getrecommendations! Published in 2019 at "Life Science Alliance"
DOI: 10.26508/lsa.201800283
Abstract: This study shows that addition of a single transcription factor binding site can be sufficient to convert a gene into a glucocorticoid receptor target. The glucocorticoid receptor (GR), a hormone-activated transcription factor, binds to a… read more here.
Keywords: target; site; gene; glucocorticoid receptor ... See more keywords