Modulation of the inflammatory response of immune cells in human peripheral blood by oxidized arachidonoyl aminophospholipids.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2018.10.003
Abstract: Aminophospholipids (APL), phosphatidylethanolamine (PE) and phosphatidylserine (PS), can be oxidized upon oxidative stress. Oxidized PE and PS have been detected in clinical samples of different pathologies and may act as modulators of the inflammatory response.… read more here.
Keywords: modulation inflammatory; response; oxpape; inflammatory response ... See more keywords
Epigenetics modulates the complexity of the response to Immune Checkpoint Blockade
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2020.103005
Abstract: a Instituto de investigaci on Biom edica de M alaga (IBIMA), Hospitales Universitarios Regional y Virgen de la Victoria, Campus de Teatinos s/n, M alaga, 29010, Spain b Laboratorio de Biología Molecular del C ancer… read more here.
Keywords: checkpoint blockade; immune checkpoint; complexity response; response immune ... See more keywords
Survival prediction and response to immune checkpoint inhibitors: A prognostic immune signature for hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Translational Oncology"
DOI: 10.1016/j.tranon.2020.100957
Abstract: Highlights • As is known to us, this is the first immune-gene-related signature of HCC which was validated in various ways.• This signature was linked to the mutation status, and we found the difference of… read more here.
Keywords: immune checkpoint; prediction response; survival prediction; response immune ... See more keywords
Abstract 5472: Utilizing response in immune checkpoint inhibitor treated cohorts improves clinical applicability of neoantigen immunogenicity predictions
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5472
Abstract: Introduction: Neoantigen-based biomarkers have improved predictions of response to immune checkpoint blockade (ICB) therapy, highlighting the importance of accurate prediction of immunogenic neoantigen candidates. A challenge in developing robust immunogenicity prediction models is limited availability… read more here.
Keywords: response immune; icb; immune checkpoint; neoantigen ... See more keywords
T-cell inflamed gene expression to predict prognosis and response to immune checkpoint inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.e15264
Abstract: e15264Background: To prove that T-cell-inflamed gene-expression profile (GEP) can predict prognosis and response to immune checkpoint inhibitors (ICIs) in the real-world study. Methods: 36 patients... read more here.
Keywords: inflamed gene; gene expression; predict prognosis; prognosis response ... See more keywords
Longitudinal monitoring of tumor response to immune checkpoint inhibitors using noninvasive diffuse reflectance spectroscopy.
Sign Up to like & getrecommendations! Published in 2021 at "Biomedical optics express"
DOI: 10.1364/boe.426879
Abstract: Immune checkpoint inhibitors have revolutionized cancer treatment. However, there are currently no methods for noninvasively and nondestructively evaluating tumor response to immune checkpoint inhibitors. We used diffuse reflectance spectroscopy to monitor in vivo tumor microenvironmental… read more here.
Keywords: immune checkpoint; spectroscopy; response immune; tumor ... See more keywords
The N6-Methyladenosine-Modified Pseudogene HSPA7 Correlates With the Tumor Microenvironment and Predicts the Response to Immune Checkpoint Therapy in Glioblastoma
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.653711
Abstract: Background Glioblastoma (GBM), one of the most aggressive tumors of the brain, has no effective or sufficient therapies. Identifying robust biomarkers for the response to immune checkpoint blockade (ICB) therapy, a promising treatment option for… read more here.
Keywords: immune checkpoint; glioblastoma; gbm; response immune ... See more keywords
DNA Damage Response and Immune Defense
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21207504
Abstract: DNA damage is the cause of numerous human pathologies including cancer, premature aging, and chronic inflammatory conditions. The DNA damage response (DDR), in turn, coordinates DNA damage checkpoint activation and promotes the removal of DNA… read more here.
Keywords: dna damage; response immune; damage response; damage ... See more keywords
Biomarkers for response to immune checkpoint inhibitors in gastrointestinal cancers
Sign Up to like & getrecommendations! Published in 2022 at "World Journal of Gastrointestinal Oncology"
DOI: 10.4251/wjgo.v14.i1.19
Abstract: Gastrointestinal (GI) cancers account for a large proportion of cancer deaths worldwide and pose a major public health challenge. Immunotherapy is considered to be one of the prominent and successful approaches in cancer treatment in… read more here.
Keywords: biomarkers response; gastrointestinal cancers; response immune; immune checkpoint ... See more keywords