Modeling near-continuous clinical endpoint as categorical: application to longitudinal exposure–response modeling of Mayo scores for golimumab in patients with ulcerative colitis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmacokinetics and Pharmacodynamics"
DOI: 10.1007/s10928-018-9610-0
Abstract: Accurate characterization of exposure–response relationship of clinical endpoints is important in drug development to identify optimal dose regimens. Endpoints with ≥ 10 ordered categories are typically analyzed as continuous. This manuscript aims to show circumstances where… read more here.
Keywords: mayo scores; modeling mayo; response modeling; exposure response ... See more keywords
Exposure-response modeling improves selection of radiation and radiosensitizer combinations.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmacokinetics and pharmacodynamics"
DOI: 10.1007/s10928-021-09784-7
Abstract: A central question in drug discovery is how to select drug candidates from a large number of available compounds. This analysis presents a model-based approach for comparing and ranking combinations of radiation and radiosensitizers. The… read more here.
Keywords: modeling improves; response modeling; exposure response; improves selection ... See more keywords
Improving categorical endpoint longitudinal exposure-response modeling through the joint modeling with a related endpoint.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmacokinetics and pharmacodynamics"
DOI: 10.1007/s10928-021-09796-3
Abstract: Exposure-response modeling is important to optimize dose and dosing regimens in clinical drug development. While primary clinical trial endpoints often have few categories and thus provide only limited information, sometimes there may be additional, more… read more here.
Keywords: response modeling; exposure response; endpoint; response ... See more keywords
Impulse Response Modeling of Underwater Optical Scattering Channels for Wireless Communication
Sign Up to like & getrecommendations! Published in 2020 at "IEEE Photonics Journal"
DOI: 10.1109/jphot.2020.3012302
Abstract: Despite the fact that underwater optical wireless communication (UOWC) systems are able to provide high-data rate links with high security, the performance of these systems presents several limitations related to the maximum achievable distance due… read more here.
Keywords: impulse response; response modeling; underwater optical; wireless communication ... See more keywords
Monte Carlo Simulation Affects Convergence of Differential Evolution: A Case of Optical Response Modeling
Sign Up to like & getrecommendations! Published in 2022 at "Algorithms"
DOI: 10.3390/a16010003
Abstract: It is known that the protein surrounding, as well as solvent molecules, has a significant influence on optical spectra of organic pigments by modulating the transition energies of their electronic states. These effects manifest themselves… read more here.
Keywords: monte carlo; response modeling; optical response; differential evolution ... See more keywords