Mutagenic assessment of chemotherapy and Smac mimetic drugs in cells with defective DNA damage response pathways
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DOI: 10.1038/s41598-018-32517-9
Abstract: DNA damaging therapies can spur the formation of therapy-related cancers, due to mis-repair of lesions they create in non-cancerous cells. This risk may be amplified in patients with impaired DNA damage responses. We disabled key… read more here.
Keywords: dna damage; smac mimetic; damage response; damage ... See more keywords
BioTarget: A Computational Framework Identifying Cancer Type Specific Transcriptional Targets of Immune Response Pathways
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DOI: 10.1038/s41598-019-45304-x
Abstract: Transcriptome data can provide information on signaling pathways active in cancers, but new computational tools are needed to more accurately quantify pathway activity and identify tissue-specific pathway features. We developed a computational method called “BioTarget”… read more here.
Keywords: pathway; immune response; th1 th2; cancer ... See more keywords
A novel Arabidopsis pathosystem reveals cooperation of multiple hormonal response-pathways in host resistance against the global crop destroyer Macrophomina phaseolina
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DOI: 10.1038/s41598-019-56401-2
Abstract: Dubbed as a “global destroyer of crops”, the soil-borne fungus Macrophomina phaseolina (Mp) infects more than 500 plant species including many economically important cash crops. Host defenses against infection by this pathogen are poorly understood.… read more here.
Keywords: hormonal response; macrophomina phaseolina; multiple hormonal; host ... See more keywords
Inside the β Cell: Molecular Stress Response Pathways in Diabetes Pathogenesis
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DOI: 10.1210/endocr/bqac184
Abstract: Abstract The pathogeneses of the 2 major forms of diabetes, type 1 and type 2, differ with respect to their major molecular insults (loss of immune tolerance and onset of tissue insulin resistance, respectively). However,… read more here.
Keywords: stress; cell; stress response; diabetes pathogenesis ... See more keywords
Nanoparticle Effects on Stress Response Pathways and Nanoparticle–Protein Interactions
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DOI: 10.3390/ijms23147962
Abstract: Nanoparticles (NPs) are increasingly used in a wide variety of applications and products; however, NPs may affect stress response pathways and interact with proteins in biological systems. This review article will provide an overview of… read more here.
Keywords: effects stress; nanoparticle effects; stress response; response pathways ... See more keywords
Interaction between proteins of the PPARγ and NFκB immune response pathways and rotavirus non-structural proteins.
Sign Up to like & getrecommendations! Published in 2022 at "Acta virologica"
DOI: 10.4149/av_2022_105
Abstract: Cells infected with MA104 rotavirus and/or transfected with plasmids expressing NSP proteins, were analyzed for expression of cellular proteins related to NFκB and PPARγ pathways and evaluated through the ELISA, luminescence, flow cytometry and Western… read more here.
Keywords: pathways rotavirus; immune response; response pathways; proteins ppar ... See more keywords