Vitamin D supplementation increases objective response rate and prolongs progression-free time in patients with advanced melanoma undergoing anti-PD1 therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer"
DOI: 10.1002/cncr.34718
Abstract: BACKGROUND Vitamin D3 is a prohormone with pleiotropic effects, including modulating the functions of the immune system and may affect the effectiveness of anti-PD-1 treatment in patients with cancer. According to the literature, the potential… read more here.
Keywords: advanced melanoma; supplementation; patients advanced; vitamin ... See more keywords
A Bayesian hierarchical monitoring design for phase II cancer clinical trials: Incorporating information on response duration into monitoring rules.
Sign Up to like & getrecommendations! Published in 2021 at "Statistics in medicine"
DOI: 10.1002/sim.9084
Abstract: We propose a Bayesian hierarchical monitoring design for single-arm phase II clinical trials of cancer treatments that incorporates the information on the duration of response (DOR) into the monitoring rules. To screen a new treatment… read more here.
Keywords: phase; response; monitoring rules; monitoring ... See more keywords
An observational study of missing data enquiry from randomised trial authors showed a poor response.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of clinical epidemiology"
DOI: 10.1016/j.jclinepi.2019.11.014
Abstract: BACKGROUND The quality of evidence from a meta-analysis might be affected by poor or inadequate reporting of individual randomized controlled trials (RCTs). The results of data request from authors has not been investigated to date.… read more here.
Keywords: missing data; response rate; response; trial authors ... See more keywords
Topical agents for oral cancer chemoprevention: A systematic review of the literature.
Sign Up to like & getrecommendations! Published in 2017 at "Oral oncology"
DOI: 10.1016/j.oraloncology.2017.02.014
Abstract: OBJECTIVES/HYPOTHESIS We review the use of topical chemoprevention agents in patients with oral potentially malignant disorders (PMD). METHODS A systematic review of studies on topical chemoprevention agents for oral PMD from 1946 to November 2016… read more here.
Keywords: agents oral; systematic review; chemoprevention; review ... See more keywords
Do student and survey characteristics affect the quality of UK undergraduate medical education course evaluation? A systematic review of the literature
Sign Up to like & getrecommendations! Published in 2019 at "Studies in Educational Evaluation"
DOI: 10.1016/j.stueduc.2019.04.011
Abstract: Abstract The purpose was to investigate whether student and survey characteristics affect the quality of course evaluation in UK undergraduate medical education. The search included several databases, five journals relevant to medical education and grey… read more here.
Keywords: course; evaluation; response rate; student survey ... See more keywords
Promoting patient engagement during care transitions after surgery using mobile technology: Lessons learned from the MobiMD pilot study.
Sign Up to like & getrecommendations! Published in 2022 at "Surgery"
DOI: 10.1016/j.surg.2021.12.018
Abstract: BACKGROUND Poorly coordinated transitions of care in complex abdominal surgery patients contribute to frequent hospital readmissions and inflated healthcare spending. Mobile health (mHealth) transitional care technologies may reduce surgical readmissions yet remain understudied in high-risk… read more here.
Keywords: study; surgery; response rate; care ... See more keywords
Immunotherapy: Desmoplasia is no barrier to PD-1 blockade in melanoma
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Clinical Oncology"
DOI: 10.1038/nrclinonc.2018.16
Abstract: for 5 years. For a disease with limited treatment options, these outcomes are very promising. “The dense stroma surrounding the DMs does not appear to be a barrier to the response to immunotherapy,” summarizes Antoni… read more here.
Keywords: dms; barrier; immunotherapy; response ... See more keywords
Efficacy of extracorporeal plasma therapy for adult native kidney patients with Primary FSGS: a Systematic review
Sign Up to like & getrecommendations! Published in 2023 at "Renal Failure"
DOI: 10.1080/0886022x.2023.2176694
Abstract: Abstract Purpose This study aimed to assess efficacy of extracorporeal plasma therapy (EPT), including plasmapheresis (PE), immunoadsorption (IA), low-density lipoprotein apheresis (LDL-A), and lymphocytapheresis (LCAP) for adult native kidney patients with primary focal segmental glomerulosclerosis… read more here.
Keywords: response rate; primary fsgs; therapy; adult native ... See more keywords
Optimal designs for phase II clinical trials with heterogeneous patient populations
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2022.2065499
Abstract: ABSTRACT We consider single-arm phase II cancer clinical trials with tumor response as the primary outcome. Oftentimes, the patient population of a phase II clinical trial consists of subpopulations with different expected response rates. A… read more here.
Keywords: optimal designs; clinical trials; response rate; response ... See more keywords
Association between objective response rate and overall survival in metastatic neuroendocrine tumors treated with radioembolization: a systematic literature review and regression analysis
Sign Up to like & getrecommendations! Published in 2020 at "Expert Review of Anticancer Therapy"
DOI: 10.1080/14737140.2020.1814748
Abstract: ABSTRACT Objectives Neuroendocrine tumors (NETs) are a heterogeneous group of cancers arising from neuroendocrine cells. The aim was to evaluate objective response rate (ORR) as a predictor of overall survival (OS) in patients with metastatic… read more here.
Keywords: resin; objective response; neuroendocrine tumors; review ... See more keywords
P437 Hyperbaric oxygen therapy for Inflammatory Bowel Disease – a systematic review
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjab076.561
Abstract: Inflammatory bowel disease (IBD) is a chronic, debilitating disease with suboptimal success rates after conventional treatments. A potential new, additional approach is hyperbaric oxygen therapy (HBOT). We aimed to evaluate the efficacy and safety of… read more here.
Keywords: response rate; hbot; disease; inflammatory bowel ... See more keywords